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Titolo:
COMPARISON OF EFFECTS OF A RANGE OF 5-HT RECEPTOR MODULATORS ON CONSUMPTION AND PREFERENCE FOR A SWEETENED ETHANOL SOLUTION IN RATS
Autore:
SILVESTRE JS; PALACIOS JM; FERNANDEZ AG; ONEILL MF;
Indirizzi:
LILLY RES CTR LTD,ERL WOOD MANOR,SUNNINGHILL RD WINDLESHAM GU20 6PH SURREY ENGLAND ALMIRALL SA,RES CTR LABS BARCELONA 08024 SPAIN
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 12, anno: 1998,
pagine: 168 - 176
SICI:
0269-8811(1998)12:2<168:COEOAR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTAGONIST ICS 205-930; ALCOHOL PREFERENCE; RITANSERIN; DRINKING; SEROTONIN; INVOLVEMENT; DECREASES; 8-OH-DPAT; BEHAVIOR; AGONISTS;
Keywords:
BUSPIRONE; 8-OH-DPAT; ETHANOL PREFERENCE; GRANISETRON; RAT; RITANSERIN; RU 24969; SEROTONIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Silvestre et al., "COMPARISON OF EFFECTS OF A RANGE OF 5-HT RECEPTOR MODULATORS ON CONSUMPTION AND PREFERENCE FOR A SWEETENED ETHANOL SOLUTION IN RATS", J PSYCHOPH, 12(2), 1998, pp. 168-176

Abstract

This study assessed the effects of a range of serotonergic agents on preference for a slightly sweetened ethanol solution (10% ethanol, 3% glucose) in rats. A two-bottle, free-choice paradigm was used following induction of ethanol consumption. The model used provides a robust and reliable level of ethanol self-administration in normal laboratory rats. Ethanol consumption was significantly and selectively reduced bythe 5-hydroxytryptamine-1A (5-HT1A) full agonist 8-OH-DPAT (0.3-1.0 mg/kg) and the 5-HT3 antagonist granisetron (0.1-1.0 mg/kg). Non-specific reductions in fluid consumption were induced by the 5-HT1B agonist RU 24969 (0.1-1.0 mg/kg) and the 5-HT2 antagonist ritanserin (1.0-6.0 mg/kg). These studies thus confirm the potential for decreasing ethanol consumption and ethanol preference of 5-HT1A agonists and 5-HT3 antagonists, but failed to find any selective effects for agents acting at5-HT1B or 5-HT2 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:37:26