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Titolo:
THE EFFECT OF SUCCINIC ACID MONOMETHYL ESTER (SAM) ON THE RESPONSES OF ISOLATED THORACIC AORTA IN STREPTOZOTOCIN-DIABETIC RATS
Autore:
OZYAZGAN S; SENSES V; INCE E; SULTUYBEK G; UTKAN T; AKKAN AG;
Indirizzi:
UNIV ISTANBUL,CERRAHPASA FAC MED,DEPT PHARMACOL TR-34303 CERRAHPASA TURKEY UNIV ISTANBUL,CERRAHPASA FAC MED,DEPT PHARMACOL TR-34303 CERRAHPASA TURKEY UNIV ISTANBUL,CERRAHPASA FAC MED,GETAM TR-34303 CERRAHPASA TURKEY UNIV KOCAELI,FAC MED,DEPT PHARMACOL KOCAELI TURKEY
Titolo Testata:
Pharmacological research
fascicolo: 1, volume: 38, anno: 1998,
pagine: 73 - 79
SICI:
1043-6618(1998)38:1<73:TEOSAM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; ADRENOCEPTOR-MEDIATED CONTRACTION; SMOOTH-MUSCLE FUNCTION; INSULIN RELEASE; VASCULAR REACTIVITY; EXTRACELLULAR CALCIUM; RESISTANCE ARTERIES; METHYL-ESTERS; GLYCERALDEHYDE PHOSPHATE; ALPHA ADRENOCEPTORS;
Keywords:
STREPTOZOTOCIN; SUCCINIC ACID MONOMETHYL ESTER; AORTA; CONTRACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
S. Ozyazgan et al., "THE EFFECT OF SUCCINIC ACID MONOMETHYL ESTER (SAM) ON THE RESPONSES OF ISOLATED THORACIC AORTA IN STREPTOZOTOCIN-DIABETIC RATS", Pharmacological research, 38(1), 1998, pp. 73-79

Abstract

Succinic acid monomethyl ester (SAM) was recently proposed as an insulinotropic tool in non-insulin-dependent diabetes mellitus. The present study was designed to define whether SAM has the vascular effect in thoracic aorta of streptozotocin (STZ)-diabetic rats. (1) Body weightsof diabetic rats were significantly increased after SAM treatment (P < 0.05). (2) Ten-day SAM treatment did not significantly affect blood glucose levels in SAM-treated control and SAM-treated STZ-diabetic rats. (3) Maximum tension responses to noradrenaline and KCI (80 mmol l(-1))were not significantly different among all the experimental groups. (4) pD(2), (-log EC50) values for noradrenaline of untreated diabeticrats were significantly less than those of controls, SAM-treated control and SAM-treated diabetic rats (P < 0.01, P < 0.001 and P < 0.05, respectively). SAM treatment normalized the decreased sensitivity of noradrenaline response in diabetic rats. (5) Fast, slow and total components of responses to noradrenaline (10(-5) mol l(-1) congruent to EC90) were not significantly different among all the experimental groups. (6) There were no significant differences between aorta precontracted with noradrenaline from controls and STZ-diabetic (untreated and SAM-treated) rats in pD(2), values and the potency of maximum relaxation toacetylcholine or in pD(2) values to sodium nitroprusside. In conclusion, 10-day SAM treatment increases the sensitivity of diabetic-aortic rings to noradrenaline compared to untreated diabetic control rats. (C) 1998 The Italian Pharmacological Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:34:52