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Titolo:
STIMULATION OF TYPE-1 AND TYPE-8 CA2+ CALMODULIN-SENSITIVE ADENYLYL CYCLASES BY THE G(S)-COUPLED 5-HYDROXYTRYPTAMINE SUBTYPE-5-HT7A RECEPTOR/
Autore:
BAKER LP; NIELSEN MD; IMPEY S; METCALF MA; POSER SW; CHAN G; OBRIETAN K; HAMBLIN MW; STORM DR;
Indirizzi:
UNIV WASHINGTON,DEPT PHARMACOL,BOX 357280 SEATTLE WA 98195 UNIV WASHINGTON,DEPT PHARMACOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT PSYCHIAT & BEHAV SCI SEATTLE WA 98195 VET AFFAIRS MED CTR SEATTLE WA 98108
Titolo Testata:
The Journal of biological chemistry
fascicolo: 28, volume: 273, anno: 1998,
pagine: 17469 - 17476
SICI:
0021-9258(1998)273:28<17469:SOTATC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMALIAN CIRCADIAN CLOCK; SEROTONIN RECEPTOR; RAT-BRAIN; MOLECULAR-CLONING; INTRACELLULAR CALCIUM; PERTUSSIS-TOXIN; MESSENGER-RNA; HIGH-AFFINITY; CELLS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
L.P. Baker et al., "STIMULATION OF TYPE-1 AND TYPE-8 CA2+ CALMODULIN-SENSITIVE ADENYLYL CYCLASES BY THE G(S)-COUPLED 5-HYDROXYTRYPTAMINE SUBTYPE-5-HT7A RECEPTOR/", The Journal of biological chemistry, 273(28), 1998, pp. 17469-17476

Abstract

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) plays an important regulatory role in developing and adult nervous systems, Withthe exception of the 5-HT3 receptor, all of the cloned serotonin receptors belong to the G protein-coupled receptor superfamily, Subtypes 5HT6 and 5-HT7 couple to stimulation of adenylyl cyclases through G(s)and display high affinities for antipsychotic and antidepressant drugs. In the brain, mRNA for 5-HT6 is found at high levels in the hippocampus, striatum, and nucleus accumbens, 5-HT7 mRNA is most abundant in the hippocampus, neocortex, and hypothalamus. To better understand howserotonin might control cAMP levels in the brain, we coexpressed 5-HT6 or 5-HT7A receptors with specific isoforms of adenylyl cyclase in HEK 293 cells. The 5-HT6 receptor functioned as a typical G(s)-coupled receptor in that it stimulated AC5, a G(s)-sensitive adenylyl cyclase, but not AC1 or AC8, calmodulin (CaM)-stimulated adenylyl cyclases thatare not activated by G(s) coupled receptors in vivo. Surprisingly, serotonin activation of 5-HT7A stimulated AC1 and AC8 by increasing intracellular Ca2+. 5-HT also increased intracellular Ca2+ in primary neuron cultures. These data define a novel mechanism for the regulation ofintracellular cAMP by serotonin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:49:00