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Titolo:
EFFECTS OF POTASSIUM CHANNEL BLOCKERS ON SYNAPTIC PLASTICITY IN THE CORTICOSTRIATAL PATHWAY
Autore:
WICKENS JR; MCKENZIE D; COSTANZO E; ARBUTHNOTT GW;
Indirizzi:
UNIV EDINBURGH,CTR NEUROSCI,SUMMERHALL EDINBURGH EH9 1QH MIDLOTHIAN SCOTLAND UNIV EDINBURGH,CTR NEUROSCI EDINBURGH EH9 1QH MIDLOTHIAN SCOTLAND UNIV OTAGO,DEPT ANAT & STRUCT BIOL DUNEDIN NEW ZEALAND UNIV EDINBURGH,SCH MED,DEPT PHYSIOL EDINBURGH EH8 9AG MIDLOTHIAN SCOTLAND
Titolo Testata:
Neuropharmacology
fascicolo: 4-5, volume: 37, anno: 1998,
pagine: 523 - 533
SICI:
0028-3908(1998)37:4-5<523:EOPCBO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; INVITRO SLICE PREPARATION; RAT STRIATAL NEURONS; NEOSTRIATAL NEURONS; DEPRESSION; HIPPOCAMPUS; TETRAETHYLAMMONIUM; MECHANISMS; FREQUENCY; INDUCTION;
Keywords:
NEOSTRIATUM; NEOCORTEX; LONG-TERM POTENTIATION; LONG-TERM DEPRESSION; CESIUM CHLORIDE; TETRAETHYLAMMONIUM CHLORIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Wickens et al., "EFFECTS OF POTASSIUM CHANNEL BLOCKERS ON SYNAPTIC PLASTICITY IN THE CORTICOSTRIATAL PATHWAY", Neuropharmacology, 37(4-5), 1998, pp. 523-533

Abstract

High-frequency stimulation (HFS) of the cerebral cortex or underlyingwhite matter usually induces long-term depression (LTD) in the corticostriatal pathway. Long-term potentiation (LTP) has been described in striatal cells exposed to extracellular tetraethylammonium (TEA). The facilitating effect of TEA may be due to blockade of K+ channels in the postsynaptic neurone or alternatively to presynaptic effects on the release of neurotransmitters such as glutamate or dopamine. We compared the effects of HFS on LTP in striatal cells in four groups of neurones. HFS in control conditions induced LTD (- 28.6 +/- 2.0% at 20 min, n = 10) whereas HFS in extracellular TEA (30 mM) induced LTP (+ 51.0 +/- 24.2% at 20 min, n = 7). LTP was not induced in cells loaded with intracellular Cs (- 20.3 +/- 11.4% at 20 min, n = 10) or intracellular TEA (-11.8 +/- 8.9% at 20 min, n = 10), despite comparable effects on postsynaptic responses to HFS. Since the effects of the intracellular KC channel blockers are limited to the cell being recorded from, thesefindings suggest that the facilitating effect of extracellular TEA onLTP induction involves a presynaptic action. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 21/09/20 alle ore 04:44:12