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Titolo:
ORAL ALUMINUM ADMINISTRATION TO RATS WITH NORMAL RENAL-FUNCTION - 2 -BODY DISTRIBUTION
Autore:
GARBOSSA G; GALVEZ G; PEREZ G; STRIPEIKIS J; TUDINO M; NESSE A;
Indirizzi:
UNIV BUENOS AIRES,FAC CIENCIAS EXACTAS & NAT,DEPT QUIM BIOL BUENOS AIRES DF ARGENTINA UNIV BUENOS AIRES,FAC CIENCIAS EXACTAS & NAT,DEPT QUIM INORGAN ANAL &QUIM FIS BUENOS AIRES DF ARGENTINA
Titolo Testata:
Human & experimental toxicology
fascicolo: 6, volume: 17, anno: 1998,
pagine: 318 - 322
SICI:
0960-3271(1998)17:6<318:OAATRW>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL ABSORPTION; BONE; DEPOSITION; FAILURE; CONTAMINATION; EXPOSURE; INFANTS; ANEMIA; MICE;
Keywords:
ORAL ALUMINUM; BONE ALUMINUM ACCUMULATION; SERUM ALUMINUM; ALUMINUM TOXICITY; BODY ALUMINUM DISTRIBUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
G. Garbossa et al., "ORAL ALUMINUM ADMINISTRATION TO RATS WITH NORMAL RENAL-FUNCTION - 2 -BODY DISTRIBUTION", Human & experimental toxicology, 17(6), 1998, pp. 318-322

Abstract

Aluminum (Al) has no known physiological function and is not considered an essential dietary compound. Nowadays, it is recognized as an element that can produce adverse effects on biological systems. The present study determined Al partitioning in the body compartments of rats that have been orally exposed for 15 weeks. Three experimental groups were studied: Controls (C, n = 19), TAl-1 (n = 10) rats receiving dailydoses of Al citrate (1.0 mu mol/g body weight) by gavage and TAl-2 (n= 13), receiving Al citrate with the drinking water (100 mmol/l). At the end of the experimental period, the Al contents of organs and serawere determined, Results are er;pressed as median and range values, Comparing the TAl-2 rats with the control ones, remarkable Al accumulation could be observed in serum (4.8/2.7 - 16.3 vs 0.4/0.2 - 1.2 mu mol/l, P < 0.001), bone [3.33/1.78 - 4.85 vs 1.00/0.48 -1.59 mu mol/g, P < 0.001), kidney (2.33/0.96 - 3.15 vs 0.52/0.22 - 2.07 mu mol/g, P < 0.001], spleen (2.22/0.70 - 4.19 vs 0.27/0.11 - 0.36 mu mol/g, P < 0.001) and liver (0.60/0.42 - 0.91 vs 0.24/0.14 - 0.78 mu mol/g, P < 0.01)while brain Al content was not significantly increased. Aluminum levels were raised in the TAl-1 group only in serum (2.8/1.3 -10.4 mu mol/g, P < 0.001), bone (1.85/1.00 - 3.41 mu mol/g, P < 0.001) and kidney (1.74/0.96 - 2.07 mu mol/g, P < 0.01). Bone Al concentration increasedin a dose-dependent manner (TAl-2 vs TAl-1, P < 0.001). The results demonstrate different tissue Al accumulation in rats chronically exposed to Al citrate, irrespective of their intact renal function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:39:45