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Titolo:
GENERATION OF REACTIVE OXYGEN SPECIES ACCOUNTS FOR CYTOTOXICITY OF ANENDOGENOUS DOPAMINERGIC NEUROTOXIN, (R)-N-METHYLSALSOLINOL, TO DIFFERENTIATED DOPAMINERGIC SH-SY5Y CELLS
Autore:
MINAMI C; DENG Y; MARUYAMA W; TAKAHASHI T; KAWAI M; NAKAHARA D; NAOI M;
Indirizzi:
INST APPL BIOCHEM,DEPT BRAIN SCI,YAGI MEM PK GIFU 5050116 JAPAN NAGOYA INST TECHNOL,DEPT APPL CHEM NAGOYA AICHI 466 JAPAN NAGOYA INST TECHNOL,DEPT BIOSCI NAGOYA AICHI 466 JAPAN NATL INST LONGEV SCI,DEPT BASIC GERONTOL,BIOCHEM & METAB LAB OBU JAPAN KONAN WOMENS COLL,DEPT FOOD & NUTR KONAN JAPAN HAMAMATSU UNIV,SCH MED,DEPT PSYCHOL HAMAMATSU SHIZUOKA 43131 JAPAN
Titolo Testata:
Journal of neural transmission
fascicolo: 4-5, volume: 105, anno: 1998,
pagine: 397 - 405
SICI:
0300-9564(1998)105:4-5<397:GOROSA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; COMPLEX-I; N-METHYL(R)SALSOLINOL; ISOQUINOLINE; INHIBITION; BRAINS; RAT; ETHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE; PERFORMANCE; ALKALOIDS;
Keywords:
CYTOTOXICITY; CATECHOL ISOQUINOLINES; ENDOGENOUS NEUROTOXIN; HYDROXYL RADICAL; OXIDATIVE PHOSPHORYLATION; SH-SY5Y CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
C. Minami et al., "GENERATION OF REACTIVE OXYGEN SPECIES ACCOUNTS FOR CYTOTOXICITY OF ANENDOGENOUS DOPAMINERGIC NEUROTOXIN, (R)-N-METHYLSALSOLINOL, TO DIFFERENTIATED DOPAMINERGIC SH-SY5Y CELLS", Journal of neural transmission, 105(4-5), 1998, pp. 397-405

Abstract

The mechanism of the cytotoxicity of endogenous dopamine-derived ethyl-6,7-dihydroxy-l,2,3,4-tetrahydroisoquinoline [(R)-N-methylsalsolinol] to differentiated human dopaminergic neuroblastoma SH-SY5Y cells wasstudied using a reduction-oxidation indicator, Alamar Blue. N-Methylsalsolinol and its oxidation product, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, were found to inhibit oxidative phosphorylation, as shownby the Redox capacity. Antioxidants, such as reduced glutathione, catalase, Tris and n-propyl gallate, reduced the cytotoxicity of N-methylsalsolinol, suggesting that hydroxyl radical was the major reactive oxygen species for the cytotoxicity. Deprenyl also protected the cells from the decrease of the Redox capavity by N-methylsalsolinol. However,antioxidants did not protect the cells from the cytotoxicity of the catechol isoquinolinium ion. The results suggest that oxidative stress induced by hydroxyl radical may be involved in the cell death of dopaminergic neurons by N-methylsalsolinol.

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Documento generato il 07/07/20 alle ore 21:48:51