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Titolo:
PHOTORECEPTOR RESCUE
Autore:
LUTHERT PJ; CHONG NHV;
Indirizzi:
INST OPHTHALMOL,BATH ST LONDON EC1V 9EL ENGLAND MOORFIELDS EYE HOSP LONDON ENGLAND
Titolo Testata:
Eye
, volume: 12, anno: 1998,
parte:, 3B
pagine: 591 - 596
SICI:
0950-222X(1998)12:<591:>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; CILIARY NEUROTROPHIC FACTOR; INHERITED RETINAL DYSTROPHY; PROGRAMMED CELL-DEATH; MESSENGER-RNAS; CONSTANT LIGHT; GANGLION-CELLS; RCS RATS; DEGENERATION; CNTF;
Keywords:
APOPTOSIS; GENE MANIPULATION; NEUROTROPHIC FACTORS; PHOTORECEPTOR; RETINAL DEGENERATION; RETINITIS PIGMENTOSA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Luthert e N.H.V. Chong, "PHOTORECEPTOR RESCUE", Eye, 12, 1998, pp. 591-596

Abstract

Photoreceptor cell death is the final, irreversible event in many blinding diseases including retinitis pigmentosa, age-related macular disease and retinal detachment. This paper examines the potential strategies for preventing photoreceptor cell death in the context of current understanding of the mechanisms of cell death. There is evidence to suggest that photoreceptor cells are inherently vulnerable, apoptosis isthe final common pathway of photoreceptor cell loss, and other retinal cells play an important role in the survival of rods and cones. Furthermore, the rationale of using neurotrophic factors as therapeutic agents in retinal degeneration is discussed in detail. Photoreceptor rescue by manipulation of genes involved in apoptosis and some pharmacological agents is also described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:44:11