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Titolo:
P5ABC OF THE TETRAHYMENA RIBOZYME CONSISTS OF 3 FUNCTIONALLY INDEPENDENT ELEMENTS
Autore:
NAITO Y; SHIRAISHI H; INOUE T;
Indirizzi:
KYOTO UNIV,FAC SCI,DEPT CHEM KYOTO 60601 JAPAN KYOTO UNIV,FAC SCI,DEPT CHEM KYOTO 60601 JAPAN
Titolo Testata:
RNA
fascicolo: 7, volume: 4, anno: 1998,
pagine: 837 - 846
SICI:
1355-8382(1998)4:7<837:POTTRC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROUP-I INTRON; RIBOSOMAL-RNA PRECURSOR; INTERVENING SEQUENCE; DOMAIN; ARCHITECTURE; INVOLVEMENT; TETRALOOP; MUTATIONS; EXCISION; REGION;
Keywords:
ACTIVATOR; COMPLEX; GROUP I INTRON; TERTIARY INTERACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
Y. Naito et al., "P5ABC OF THE TETRAHYMENA RIBOZYME CONSISTS OF 3 FUNCTIONALLY INDEPENDENT ELEMENTS", RNA, 4(7), 1998, pp. 837-846

Abstract

P5abc domain of Tetrahymena LSU intron functions as an activator thatis not essential for but enhances the activity of the ribozyme eitherwhen present in cis or when added in trans. This domain contains three regions (A-rich bulge, L5b, and L5c) that have been demonstrated to interact with the rest of the intron. Although these regions are presumably important for efficient activation, the role of each element is not understood in the mechanism of activation. We employed circularly permuted introns and examined the roles of each element. The results show that each of the three elements can activate the intron independently. We also found that a correlation between the activation by P5abc and the physical affinity of P5abc to the intron exists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:10:58