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Titolo:
EFFECTS OF MIBEFRADIL, A NOVEL CALCIUM-CHANNEL BLOCKING-AGENT WITH T-TYPE ACTIVITY, IN ACUTE EXPERIMENTAL MYOCARDIAL-ISCHEMIA - MAINTENANCEOF VENTRICULAR-FIBRILLATION THRESHOLD WITHOUT INOTROPIC COMPROMISE
Autore:
MULLER CA; OPIE LH; MCCARTHY J; HOFMANN D; PINEDA CA; PEISACH M;
Indirizzi:
UNIV CAPE TOWN,SCH MED,HEART RES UNIT,CAPE HEART CTR,MED RES COUNCIL,HEART RES GRP ZA-7925 CAPE TOWN SOUTH AFRICA NATL ACCELERATOR CTR CAPE TOWN SOUTH AFRICA
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 1, volume: 32, anno: 1998,
pagine: 268 - 274
SICI:
0735-1097(1998)32:1<268:EOMANC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC ADENOSINE-MONOPHOSPHATE; PERFUSED RAT-HEART; INTRACELLULAR CALCIUM; CA2+ CHANNELS; RO 40-5967; ANTAGONIST; ARRHYTHMIAS; RO-40-5967; VERAPAMIL; MYOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Muller et al., "EFFECTS OF MIBEFRADIL, A NOVEL CALCIUM-CHANNEL BLOCKING-AGENT WITH T-TYPE ACTIVITY, IN ACUTE EXPERIMENTAL MYOCARDIAL-ISCHEMIA - MAINTENANCEOF VENTRICULAR-FIBRILLATION THRESHOLD WITHOUT INOTROPIC COMPROMISE", Journal of the American College of Cardiology, 32(1), 1998, pp. 268-274

Abstract

Objectives.We tested whether mibefradil, a selective T-type calcium channel blocking agent, could differentially inhibit experimental ventricular arrhythmogenesis more than contractility during acute regional ischemia and reperfusion compared with that during L-channel blockade by verapamil. Background. T-type calcium channels are found in nodal and conduction tissue and in vascular smooth muscle, but in much lower density in contractile myocardium. The potential role of mibefradil inventricular arrhythmogenesis remains unclear. Methods. Mibefradil (Ro40-5967, 1 mg/kg body weight intravenously [IV]) was given as a bolus30 min before anterior descending coronary artery ligation, followed by 2 mg/kg per h TV during 20 min of ischemia and 25 min of reperfusion in open chest pigs. In a second group, mibefradil,vas given in a dose twice as high. A third group received verapamil (0.3 mg/kg IV), followed by an infusion of 0.6 mg/kg per h. Results. During the ischemic period, the low (clinically relevant) dose of mibefradil prevented the fall of the ventricular fibrillation threshold, without depressing themaximal rate of pressure development of the left ventricle (LVmax dP/dt). This low dose increased left ventricular blood how whereas peripheral arterial pressure remained unchanged. The higher dose of both mibefradil and verapamil was antiarrhythmic during ischemia, at the cost of depressed contractile activity. During reperfusion, only the higherdose of mibefradil and verapamil was antiarrhythmic but both depressed contractile activity. Conclusions. mibefradil is antiarrhythmic,,without inotropic compromise. Speculatively, both T-type and L-type calcium channel blockade are involved in these effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 03:00:18