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Titolo:
CARDIAC SYMPATHETIC INNERVATION IN PATIENTS WITH IDIOPATHIC RIGHT-VENTRICULAR OUTFLOW TRACT TACHYCARDIA
Autore:
SCHAFERS M; LERCH H; WICHTER T; RHODES CG; LAMMERTSMA AA; BORGGREFE M; HERMANSEN F; SCHOBER O; BREITHARDT G; CAMICI PG;
Indirizzi:
HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT,DUCANE RD LONDON W12 0HS ENGLAND HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT LONDON W12 0HS ENGLAND UNIV MUNSTER,DEPT NUCL MED D-4400 MUNSTER GERMANY UNIV MUNSTER,DEPT CARDIOL & ANGIOL D-4400 MUNSTER GERMANY UNIV MUNSTER,INST ARTERIOSCLEROSIS RES D-4400 MUNSTER GERMANY UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,HAMMERSMITH HOSP,SCH MED LONDON ENGLAND
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 1, volume: 32, anno: 1998,
pagine: 181 - 186
SICI:
0735-1097(1998)32:1<181:CSIIPW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BETA-ADRENOCEPTORS; POSITRON EMISSION TOMOGRAPHY; CORONARY-ARTERY DISEASE; HYPERTROPHIC CARDIOMYOPATHY; DILATED CARDIOMYOPATHY; HEART-FAILURE; SCINTIGRAPHY; ARRHYTHMIAS; REDUCTION; CGP-12177;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M. Schafers et al., "CARDIAC SYMPATHETIC INNERVATION IN PATIENTS WITH IDIOPATHIC RIGHT-VENTRICULAR OUTFLOW TRACT TACHYCARDIA", Journal of the American College of Cardiology, 32(1), 1998, pp. 181-186

Abstract

Objectives. This study investigated the neuronal reuptake of norepinephrine (uptake-1) and the beta-adrenoceptor density in patients,vith idiopathic right ventricular outflow tract tachycardia (RVO-VT). Background. Clinical findings, such as the inducibility of ventricular tachycardia by stress or catecholamine infusion, and the therapeutic efficacy of antiarrhythmic drugs with antiadrenergic properties suggest abnormalities of cardiac sympathetic innervation in patients,vith idiopathic RVO-VT. Methods. Eight patients with idiopathic RVO-VT and a total of 29 age-matched control subjects were investigated by positron emission tomography using [C-11] hydroxyephedrine (HED) (volume of distribution of [C-11]HED) to assess presynaptic norepinephrine reuptake; [C-11] CGP 12177 (maximal binding capacity of [C-11]CGP 12177) to measure postsynaptic beta-adrenoceptor density; and oxygen-15-labeled water for quantification of myocardial blood flow (MBF). Results. Both myocardial catecholamine reuptake and beta adrenoceptor density were significantly reduced in patients with idiopathic RVO-VT. The volume of distribution of [C-11]HED in patients with RVO-VT was (mean +/- SD) 41.0 +/-13.5 versus 71.0 +/- 18.8 ml/g in control subjects (p < 0.002). The maximal binding capacity of the beta-adrenoceptor antagonist [C-11] CGP12177 was 6.8 +/- 1.2 pmol/g in patients with RVO-VT versus 10.2 +/- 2.9 pmol/g in control subjects (p < 0.004). There were no significant differences in MBF at rest (0.98 +/- 0.14 vs. 0.97 +/- 0.24 ml/min perg, p = NS) between patients with RVO-VT and control subjects. Conclusions. The findings of the present study suggest that myocardial beta-adrenoceptor downregulation in patients with RVO-VT occurs subsequentlyto increased local synaptic catecholamine levels caused by impaired catecholamine reuptake.

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Documento generato il 05/07/20 alle ore 03:03:04