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Titolo:
ACCURATE NONINVASIVE QUANTITATION OF BLOOD-FLOW, CROSS-SECTIONAL LUMEN VESSEL AREA AND WALL SHEAR-STRESS BY 3-DIMENSIONAL PARABOLOID MODELING OF MAGNETIC-RESONANCE-IMAGING VELOCITY DATA
Autore:
OYRE S; RINGGAARD S; KOZERKE S; PAASKE WP; ERLANDSEN M; BOESIGER P; PEDERSEN EM;
Indirizzi:
AARHUS UNIV HOSP,DEPT CARDIOTHORAC & VASC SURG T,SKEJBY SYGEHUS DK-8200 AARHUS N DENMARK AARHUS UNIV HOSP,SKEJBY SYGEHUS,INST EXPT CLIN RES,MRI RES CTR DK-8000 AARHUS DENMARK AARHUS UNIV,DEPT BIOSTAT AARHUS DENMARK UNIV ZURICH,INST BIOMED ENGN & MED INFORMAT ZURICH SWITZERLAND SWISS FED INST TECHNOL ZURICH SWITZERLAND
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 1, volume: 32, anno: 1998,
pagine: 128 - 134
SICI:
0735-1097(1998)32:1<128:ANQOBC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAROTID-ARTERY; ABDOMINAL-AORTA; IN-VIVO; MR; QUANTIFICATION; ATHEROSCLEROSIS; PATTERNS; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
S. Oyre et al., "ACCURATE NONINVASIVE QUANTITATION OF BLOOD-FLOW, CROSS-SECTIONAL LUMEN VESSEL AREA AND WALL SHEAR-STRESS BY 3-DIMENSIONAL PARABOLOID MODELING OF MAGNETIC-RESONANCE-IMAGING VELOCITY DATA", Journal of the American College of Cardiology, 32(1), 1998, pp. 128-134

Abstract

Objectives. We present a new method in which a priori knowledge of the blood velocity fields within the boundary layer at the vessel wall, combined with acquisition of high resolution magnetic resonance imaging (MRI) blood velocity data, allow exact modeling at the subpixel level. Background. Methods are lacking for accurate, noninvasive estimation of blood flow, dynamic cross-sectional lumen vessel area and wall shear stress. Methods. Using standard acquisition of MRI blood flow velocity data, we fitted all data points (n = 69) within the boundary layer of the velocity profile to a three dimensional paraboloid, which enabled calculation of absolute volume blood dow, circumferential vessel wall position, lumen vessel area and wall sheer stress. The method wastested in a 8.00 + 0.01-mm diameter glass tube model and applied in vivo to the common carotid artery of seven volunteers. Results. In vitro the lumen area was assessed with a mean error of 0.6%. The 95% confidence interval included the specified tube dimensions. Common carotid mean blood flow was 7.42 ml/s, and mean (standard error) diastolic/systolic vessel area was 33.25 (0.72 [2.2%])/43.36 (0.65 [1.5%]) mm(2). Mean/peak wall shear stress,vas 0.95 (0.04 [4.2%])/2.56 (0.08 [3.1%]) N/m(2). Conclusions. We describe a new noninvasive method for highly accurate estimation of blood flow, cross sectional lumen vessel area andwall shear stress. In vitro results and statistical analysis demonstrate the feasibility of the method, and the first in vivo results are comparable to published data. (C) 1998 by the American College of Cardiology.

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Documento generato il 19/09/20 alle ore 09:20:37