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Titolo:
PLASMA L-ARGININE CONCENTRATION, OXYGENATION INDEX, AND SYSTEMIC BLOOD-PRESSURE IN PREMATURE-INFANTS
Autore:
ZAMORA SA; AMIN HJ; MCMILLAN DD; FICK GH; BUTZNER JD; PARSONS HG; SCOTT RB;
Indirizzi:
HLTH SCI CTR,DEPT PEDIAT,3330 HOSP DR NW CALGARY AB T2N 4N1 CANADA UNIV CALGARY,DIV GASTROENTEROL CALGARY AB CANADA UNIV CALGARY,DIV NEONATOL CALGARY AB CANADA UNIV CALGARY,DEPT PEDIAT CALGARY AB T2N 1N4 CANADA UNIV CALGARY,DEPT COMMUNITY HLTH SCI CALGARY AB CANADA
Titolo Testata:
Critical care medicine
fascicolo: 7, volume: 26, anno: 1998,
pagine: 1271 - 1276
SICI:
0090-3493(1998)26:7<1271:PLCOIA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERSISTENT PULMONARY-HYPERTENSION; RESPIRATORY-DISTRESS SYNDROME; HYALINE-MEMBRANE DISEASE; AMINO-ACID SUPPLEMENTATION; NITRIC-OXIDE SYNTHESIS; VASCULAR-RESISTANCE; NEWBORN; PRETERM; DYSFUNCTION; DEFICIENCY;
Keywords:
ARGININE; NITRIC OXIDE; OXYGENATION INDEX; BLOOD PRESSURE; PREMATURE INFANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Zamora et al., "PLASMA L-ARGININE CONCENTRATION, OXYGENATION INDEX, AND SYSTEMIC BLOOD-PRESSURE IN PREMATURE-INFANTS", Critical care medicine, 26(7), 1998, pp. 1271-1276

Abstract

Objective: To determine the relationships between plasma L-arginine concentrations and the severity of respiratory distress syndrome (RDS) or systemic blood pressure in premature infants, Design: Prospective, observational study, Setting: Neonatal intensive care, tertiary referral hospital, Subjects: Fifty-three premature infants, Interventions: We measured arginine and nutritional intake, plasma arginine concentration, total amino acid concentrations, and blood pressure on days 3, 7,14, and 21 of life, In 33 infants who received assisted ventilation, oxygenation index could be calculated to reflect the severity of RDS, The relationships between plasma arginine and oxygenation index or blood pressure were analyzed using multiple lineary regression, Measurements and Main Results: On day 3, plasma arginine concentrations were decreased compared with normal published values. Arginine concentrationsincreased with the day of life of measurement (p <.001) and with arginine intake (p <.001), After adjusting for arginine intake and day of life, an inverse relationship was found between oxygenation index and plasma arginine concentrations: (p = .025), No similar relationship was found between oxygenation index and the concentration of total aminoacids, A weak positive relationship was found between plasma arginineconcentration and systemic blood pressure. Conclusions: Increments inthe oxygenation index, reflective of an increased severity of Pus, are associated with a decrease in plasma arginine concentration. This finding may reflect arginine consumption by the nitric oxide synthase pathway in the lungs of premature infants with RDS, or may be explained by increased arginine catabolism. The lack of a similar relationship between total plasma amino acids and oxygenation index supports the first interpretation.

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Documento generato il 25/09/20 alle ore 22:29:21