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Titolo:
HUMAN SWI SNF INTERCONVERTS A NUCLEOSOME BETWEEN ITS BASE STATE AND ASTABLE REMODELED STATE/
Autore:
SCHNITZLER G; SIF S; KINGSTON RE;
Indirizzi:
MASSACHUSETTS GEN HOSP,DEPT BIOL MOL BOSTON MA 02114 MASSACHUSETTS GEN HOSP,DEPT BIOL MOL BOSTON MA 02114
Titolo Testata:
Cell (Cambridge)
fascicolo: 1, volume: 94, anno: 1998,
pagine: 17 - 27
SICI:
0092-8674(1998)94:1<17:HSSIAN>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTIONAL ACTIVATORS; RETINOBLASTOMA PROTEIN; CHROMATIN STRUCTURE; COMPLEX; DNA; BINDING; DISRUPTION; SEQUENCES; RECEPTOR; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
G. Schnitzler et al., "HUMAN SWI SNF INTERCONVERTS A NUCLEOSOME BETWEEN ITS BASE STATE AND ASTABLE REMODELED STATE/", Cell (Cambridge), 94(1), 1998, pp. 17-27

Abstract

The human SWI/SNF complex remodels nucleosome structure in an ATP-dependent manner, although the nature of this change has not been determined. Here we show that hSWI/SNF and ATP generate an altered nucleosomal structure that is stable in the absence of SWI/SNF. This product hasan altered sensitivity to digestion by DNAse, restriction enzymes, and micrococcal nuclease, and an increased affinity for GAL4. It has thesame protein composition but is approximately twice the size of a normal nucleosome. Incubation of the altered nucleosome with hSWI/SNF converts this structure back to a standard nucleosome in an ATP-dependentprocess. These results suggest that hSWI/SNF acts by facilitating an exchange between normal and altered, more accessible, nucleosome conformations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 04:05:44