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Titolo:
DIRECT IN-VIVO MEASUREMENT OF GASTRIC MICROVASCULAR PRESSURES IN THE RAT
Autore:
PETIPETERDI J; HAMAR P; KOVACS G; ROSIVALL L;
Indirizzi:
SEMMELWEIS UNIV MED,SCH MED,INST PATHOPHYSIOL,NAGYVARAD TER 4 H-1089 BUDAPEST HUNGARY
Titolo Testata:
Microvascular research (Print)
fascicolo: 3, volume: 55, anno: 1998,
pagine: 223 - 229
SICI:
0026-2862(1998)55:3<223:DIMOGM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL MUSCLE; MICROCIRCULATION; MUCOSA; STRESS; INVIVO;
Keywords:
MICROVASCULAR PRESSURES; MICROPUNCTURE; INTRAVITAL MICROSCOPY; GASTRIC MICROCIRCULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J. Petipeterdi et al., "DIRECT IN-VIVO MEASUREMENT OF GASTRIC MICROVASCULAR PRESSURES IN THE RAT", Microvascular research (Print), 55(3), 1998, pp. 223-229

Abstract

There are no direct data available on micropressures in the gastric microcirculation in spite of its pivotal role in the development of acute gastric mucosal lesions. Our goal was to develop an in vivo method to directly measure intravascular pressure and vessel diameter in various gastric microvessels. This paper describes methods and procedural details of our novel preparation of the exteriorized rat stomach for vascular micropuncture studies. The stomach of the anesthetized rat wasfixed with minimal surgery in a temperature-controlled gastric chamber. Two preparations were used, both from the serosal side: a seromuscular preparation to study the circulation of superficial outer muscularlayers and a submucosal preparation-following careful dissection of the seromuscular layer-to study the submucosal and deeper mucosal microcirculations. Intravascular hydrostatic pressure was measured with a servo-null micropressure measuring system, while vessel diameter was evaluated on the television screen with videometry. Data (average +/- SE) were obtained from muscular arterioles (20.8 +/- 0.93 mu m; 29.8 +/-1.32 mmHg), venules (23.4 +/- 1.61 mu m; 18.1 +/- 0.61 mmHg), submucosal arterioles (50.9 +/- 3.55 mu m; 55.4 +/- 2.78 mmHg), venules (53.7+/- 2.06 mu m; 21.4 +/- 0.73 mmHg), and deeper mucosal arterioles (20.2 +/- 1.06 mu m; 33.8 +/- 0.81 mmHg), venules (29.9 +/- 1.17 mu m; 25.8 +/- 0.47 mmHg), at a systemic arterial pressure of 110 +/- 2.4 mmHg(n = 10 each from 14 animals). Further experiments demonstrated the applicability of this method to examine the effects of systemic blood pressure reduction and local application of vasoactive agents on the gastric microcirculation. This method is useful for analyzing the microcirculation of the stomach in vivo under different experimental conditions. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 12:03:45