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Titolo:
TRABECULECTOMY WITH INTRAOPERATIVE 5-FLUOROURACIL
Autore:
SIDOTI PA; CHOI JC; MORINELLI EN; LEE PP; BAERVELDT G; MINCKLER DS; HEUER DK;
Indirizzi:
NEW YORK EYE & EAR INFIRM,DEPT OPHTHALMOL,310 E 14TH ST NEW YORK NY 10003 UNIV SO CALIF,SCH MED LOS ANGELES CA 00000 DOHENY EYE INST LOS ANGELES CA 90033
Titolo Testata:
Ophthalmic surgery
fascicolo: 7, volume: 29, anno: 1998,
pagine: 552 - 561
SICI:
0022-023X(1998)29:7<552:TWI5>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLAUCOMA FILTRATION SURGERY; ADJUNCTIVE MITOMYCIN-C; FILTERING SURGERY; POSTOPERATIVE 5-FLUOROURACIL; HYPOTONY; FLUOROURACIL; ENDOPHTHALMITIS; FIBROBLASTS; RABBIT; EYES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Sidoti et al., "TRABECULECTOMY WITH INTRAOPERATIVE 5-FLUOROURACIL", Ophthalmic surgery, 29(7), 1998, pp. 552-561

Abstract

BACKGROUND AND OBJECTIVE: To investigate the outcome and complicationrates of trabeculectomy following the combined use of intraoperative,topical 5-fluorouracil (5-FU) and low-dose, postoperative subconjunctival 5-FU injections. PATIENTS AND METHODS: Forty-one eyes of 41 patients with advanced, medically uncontrolled glaucoma underwent trabeculectomy with intraoperative episcleral application of 5-FU (50 mg/ml for5 minutes). A variable number of subconjunctival 5-FU injections wereadministered postoperatively at the discretion of the operating surgeon. RESULTS: Six-, 12-, and 15-month Life-table success rates (5 mm Hgless than or equal to intraocular pressure [IOP less than or equal to21 mm Hg) were 100%, 97%, and 83%, respectively. Mean postoperative IOP was 12.1 +/- 4.3 mm Hg. An average of 2.2 +/- 1.6 (range 0 to 7) supplemental subconjunctival 5-FU injections were administered postoperatively. Corneal epithelial erosions developed in 7 (17%) of the eyes. Five of 7 patients who underwent subsequent surgical procedures maintained successful control of IOP at an average of 11.0 +/- 4.8 (range 5 to 16) months after the secondary surgery. CONCLUSION: Trabeculectomy with intraoperative 5-FU is effective in controlling IOP while possibly minimizing the need for frequent postoperative injections and the occurrence of corneal epitheliopathy.

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Documento generato il 30/11/20 alle ore 07:11:28