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Titolo:
EFFECTS OF RHINOVIRUS INFECTION ON HYDROGEN PEROXIDE-INDUCED ALTERATIONS OF BARRIER FUNCTION IN THE CULTURED HUMAN TRACHEAL EPITHELIUM
Autore:
OHRUI T; YAMAYA M; SEKIZAWA K; YAMADA N; SUZUKI T; TERAJIMA M; OKINAGA S; SASAKI H;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU,SEIRYO-MACHI 1-1 SENDAI MIYAGI 980 JAPAN TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU SENDAI MIYAGI 980 JAPAN
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 1, volume: 158, anno: 1998,
pagine: 241 - 248
SICI:
1073-449X(1998)158:1<241:EORIOH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL LINE; ADHESION; ASTHMA; ICAM-1; PERMEABILITY; RECEPTOR; CHILDREN; ANTIGEN; POLLEN; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T. Ohrui et al., "EFFECTS OF RHINOVIRUS INFECTION ON HYDROGEN PEROXIDE-INDUCED ALTERATIONS OF BARRIER FUNCTION IN THE CULTURED HUMAN TRACHEAL EPITHELIUM", American journal of respiratory and critical care medicine, 158(1), 1998, pp. 241-248

Abstract

To investigate whether rhinovirus infection impairs epithelial barrier functions, human rhinovirus 14 (HRV-14) was infected to primary cultures of human tracheal epithelial cells and experiments were performedon Day 2 after HRV-14 infection. Hydrogen peroxide (H2O2; 3 x 10(-4) M) increased electrical conductance (G) across the epithelial cell sheet measured with Ussing's chamber methods. Exposure of the epithelial cells to HRV-14 had no effect on H2O2-induced increases in G and [H-3]mannitol flux through the cultured epithelium in the control condition, but it markedly potentiated H2O2-induced increases in both parameters in IL-1 beta (100 U/ml) pretreated condition. However, pretreatment with TNF-alpha (100 U/ml) was without effect. IL-1 beta enhanced the intercellular adhesion molecule-1 (ICAM-1) expression assessed by immunohistochemical analysis and susceptibility of epithelial cells to HRV-14 infection. An antibody to ICAM-1 inhibited HRV-14 infection of epithelial cells and abolished H2O2-induced increases in G and [H-3]mannitol flux in IL-1 beta-pretreated epithelial cells with HRV-14 infection. These results suggest that rhinovirus infection may reduce barrier functions in the airway epithelium in association with upregulation of ICAM-1 expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:38:21