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Titolo:
INVOLVEMENT OF TACHYKININ NK3 RECEPTORS IN CITRIC ACID-INDUCED COUGH AND BRONCHIAL RESPONSES IN GUINEA-PIGS
Autore:
DAOUI S; COGNON C; NALINE E; EMONDSALT X; ADVENIER C;
Indirizzi:
UNIV PARIS 05,PHARMACOL LAB,15 RUE ECOL MED F-75006 PARIS FRANCE UNIV PARIS 05,PHARMACOL LAB F-75006 PARIS FRANCE SANOFI RECH F-34184 MONTPELLIER FRANCE
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 1, volume: 158, anno: 1998,
pagine: 42 - 48
SICI:
1073-449X(1998)158:1<42:IOTNRI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; SUBSTANCE-P; NONPEPTIDE ANTAGONIST; MICROVASCULAR LEAKAGE; SELECTIVE AGONISTS; AIRWAY FUNCTION; SENSORY NERVES; MOUSE EAR; SR 48968; C-FIBERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
S. Daoui et al., "INVOLVEMENT OF TACHYKININ NK3 RECEPTORS IN CITRIC ACID-INDUCED COUGH AND BRONCHIAL RESPONSES IN GUINEA-PIGS", American journal of respiratory and critical care medicine, 158(1), 1998, pp. 42-48

Abstract

Aerosolized citric acid induces several pulmonary effects including bronchoconstriction, airway inflammation, and cough. Evidence from the use of tachykinin NK1 and NK2 receptor antagonists, as well as chronictreatment with high doses of capsaicin, have suggested that these effects are mediated through the release of tachykinins from sensory nerve endings. In the present study, we have investigated the effects of atachykinin NK3 receptor antagonist, SR 142801 (osanetant), on cough, bronchoconstriction, and bronchial hyperresponsiveness induced by aerosolized citric acid (0.4 M) in guinea pigs. SR 142801, at 0.3 and 1 mg. kg(-1) by intraperitoneal route, significantly inhibited cough in conscious guinea pigs by 57 +/- 3 and 62 +/- 10% (n = 8), respectively. In anaesthetized guinea pigs, it failed to inhibit the bronchoconstriction induced by citric acid when given alone but abolished it when combined with the tachykinin NK2 receptor antagonist, SR 48968 (saredutant). In guinea pigs pretreated with thiorphan (1 mg . kg(-1)), aerosolized citric acid (0.4 M, 1 h) induced airway hyperresponsiveness 24 h later, displayed by an exaggerated response to the bronchoconstrictor effect of acetylcholine. A microvascular leakage hypersensitivity alsooccurred and was demonstrated by a potentiation of the plasma proteinextravasation from bronchial vessels induced by histamine. When givenonce intraperitoneally at 1 mg . kg(-1) 30 min before the citric acidexposure, SR 142801 inhibited both hyperresponsiveness to acetylcholine and the potentiation of histamine-induced increase in microvascularpermeability. The results suggest that tachykinin NK3 receptors are involved in citric acid-induced effects on airways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 19:52:25