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Titolo:
LAVAGE ADMINISTRATION OF DILUTE SURFACTANTS AFTER ACUTE LUNG INJURY IN NEONATAL PIGLETS
Autore:
BALARAMAN V; MEISTER J; KU TL; SOOD SL; TAM E; KILLEEN J; UYEHARA CFT; EGAN E; EASA D;
Indirizzi:
KAPIOLANI MED CTR WOMEN & CHILDREN,CLIN RES CTR,1319 PUNAHOU ST HONOLULU HI 96826 KAPIOLANI MED CTR WOMEN & CHILDREN,CLIN RES CTR HONOLULU HI 96826 UNIV HAWAII,JOHN A BURNS SCH MED,DEPT PEDIAT MED & PATHOL HONOLULU HI96822 TRIPLER ARMY MED CTR,DEPT CLIN INVEST HONOLULU HI 00000 SUNY BUFFALO,DEPT PEDIAT & PHYSIOL BUFFALO NY 14260
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 1, volume: 158, anno: 1998,
pagine: 12 - 17
SICI:
1073-449X(1998)158:1<12:LAODSA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; EXOGENOUS SURFACTANT; INFANTS; FAILURE; MODEL; EXOSURF(R); ALVEOLAR; RABBITS; SEPSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
V. Balaraman et al., "LAVAGE ADMINISTRATION OF DILUTE SURFACTANTS AFTER ACUTE LUNG INJURY IN NEONATAL PIGLETS", American journal of respiratory and critical care medicine, 158(1), 1998, pp. 12-17

Abstract

Exogenous surfactant therapy is not standard in the acute respiratorydistress syndrome (ARDS) because of a lack of proven benefit. Nonuniform surfactant distribution after either bolus or aerosol administration may be an important factor limiting response. In a previous study of acute lung injury, we demonstrated that lavage administration of Exosurf (13.5 mg phospholipid/ml) was both effective and distributed uniformly in the lungs. Since the endogenous surfactant pool is much smaller than the typical dose of exogenous surfactant administered, we hypothesized that dilute surfactant preparations (44.5 mg phospholipid/ml)administered by lung lavage would be equally effective in reversing pulmonary dysfunction in a piglet model of acute lung injury. We compared three dilute surfactants: Infasurf (n = 5), KL4-Surfactant (n = 6),and Exosurf (n = 5) with controls (n = 6) and undiluted Exosurf (13.5mg phospholipid/ml; n = 6). All dilute surfactant preparations were effective in improving oxygenation and other parameters of pulmonary function. Surfactant administered by lavage resulted in uniform lung distribution. We conclude that dilute surfactants administered by lung lavage are effective in reversing pulmonary dysfunction after acute lunginjury. We speculate that doses in the range of 20-40 mg phospholipid/kg may be adequate to improve lung function in ARDS when exogenously administered surfactant is uniformly distributed in the lung.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:43:53