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Titolo:
NORMAL FRONTAL PERFUSION IN PATIENTS WITH FROZEN GAIT
Autore:
FABRE N; BREFEL C; SABATINI U; CELSIS P; MONTASTRUC JL; CHOLLET F; RASCOL O;
Indirizzi:
NATL INST HLTH & MED RES,INSERM,U455,LAB PHARMACOL MED & CLIN,37 ALLEES J GUESDE F-31073 TOULOUSE FRANCE NATL INST HLTH & MED RES,INSERM,U455,LAB PHARMACOL MED & CLIN F-31073TOULOUSE FRANCE DEPT NEUROL TOULOUSE FRANCE DEPT CLIN PHARMACOL TOULOUSE FRANCE MEDITERRANEAN INST NEUROSCI NEUROMED POZZILLI ITALY
Titolo Testata:
Movement disorders
fascicolo: 4, volume: 13, anno: 1998,
pagine: 677 - 683
SICI:
0885-3185(1998)13:4<677:NFPIPW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; IDIOPATHIC PARKINSONS-DISEASE; SUPPLEMENTARY MOTOR AREA; PURE AKINESIA; IGNITION FAILURE; LEWY BODY; HYPOMETABOLISM; APOMORPHINE;
Keywords:
FREEZING; PARKINSONS DISEASE; PROGRESSIVE SUPRANUCLEAR PALSY; ISOLATED GAIT IGNITION FAILURE; FRONTAL LOBE; RCBF; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
N. Fabre et al., "NORMAL FRONTAL PERFUSION IN PATIENTS WITH FROZEN GAIT", Movement disorders, 13(4), 1998, pp. 677-683

Abstract

We have studied the frontal perfusion in the resting condition of twogroups of patients with frozen gait: 10 patients with the syndrome of''isolated gait ignition failure'' (IGIF) and 8 patients with idiopathic Parkinson's disease (PD) and severe ''off '' freezing. These patients were compared with two other groups: one including 20 age-matched volunteers as normal control subjects and the other one including 12 patients with progressive supranuclear palsy (PSP) as a positive control with expected frontal hypoperfusion. Frontal perfusion was assessed using single photon emission computed tomography (SPECT) regional cerebral blood flow measurement with intravenous (133)Xenon. A significantfrontal hypoperfusion was only present in the PSP group but not in the three others. These results do not support the hypothesis that starthesitations and freezing when walking are related to a frontal lobe dysfunction. However, it is possible that frontal neuronal dysfunction occurs without measurable cerebral blood flow changes in the resting condition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:54:33