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Titolo:
ELEVATED [H-3]INOSITOL 1,4,5-TRISPHOSPHATE BINDING-SITES AND EXPRESSED INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR PROTEIN LEVEL IN PLATELETS OF DEPRESSED-PATIENTS
Autore:
DWIVEDI Y; JANICAK PG; PANDEY GN;
Indirizzi:
UNIV ILLINOIS,DEPT PSYCHIAT,INST PSYCHIAT,1601 W TAYLOR,M-C 912 CHICAGO IL 60612 UNIV ILLINOIS,DEPT PSYCHIAT,INST PSYCHIAT CHICAGO IL 60612
Titolo Testata:
Psychopharmacology
fascicolo: 1, volume: 138, anno: 1998,
pagine: 47 - 54
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BLOOD PLATELETS; 1,4,5-TRISPHOSPHATE RECEPTOR; INTRACELLULAR CA-2+; CALCIUM; RELEASE; SEROTONIN; 5-HYDROXYTRYPTAMINE; STIMULATION; ACTIVATION; MEMBRANES;
Keywords:
INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; HUMAN PLATELET; DEPRESSION; IMMUNOLABELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
Y. Dwivedi et al., "ELEVATED [H-3]INOSITOL 1,4,5-TRISPHOSPHATE BINDING-SITES AND EXPRESSED INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR PROTEIN LEVEL IN PLATELETS OF DEPRESSED-PATIENTS", Psychopharmacology, 138(1), 1998, pp. 47-54

Abstract

Several reports suggest that serotonin(2A) (5HT(2A)) receptors and this receptor-mediated phosphatidyl inositol(PI) hydrolysis signal transduction system are altered in platelets of depressed patients. Inositol 1,4,5-trisphosphate (Ins[1,4,5]P-3), an important component of the PI signaling system, plays a crucial role in various physiological processes by releasing Ca2+ from intracellular stores after binding with Ins(1,4,5)P-3 receptors. To examine the role of Ins(1 4,5)P3 receptors in depression, we determined [H-3]Ins(1,4,5)P-3 binding sites and expressed protein levels of Ins(1,4,5)P-3 receptors in platelets of depressed patients (n = 15) and normal control subjects (n = 17). We observed that the mean B-max of [H-3]Ins(1,4,5)P-3 binding to Ins(1,4,5)P-3 receptors was significantly higher in platelets of depressed subjects compared with normal control subjects, whereas there was no significantdifference in K-D between these two groups. The immune-detectable expressed level of Ins(1,4,5)P-3 receptor protein was also significantly increased in depressed patients in contrast to the levels of normal control subjects. Moreover, a significant correlation was observed in B-max and the protein level of Ins(1,4,5)P-3 receptors. The increase in the number of [H-3]Ins(1,4,5)P-3 binding sites in platelets of depressed subjects appears to be due to an increase in the amount of Ins(1,4,5)P-3 receptor proteins. These results suggest that Ins(1,4,5)P-3 receptors receptors may be involved in the pathophysiology of depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 00:48:41