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Titolo:
TREATMENT OF INTRAHEPATIC RECURRENCE AFTE R RESECTION OF HEPATOCELLULAR-CARCINOMA
Autore:
IDRISSI MSS; VONS C; BORGONOVO G; MARIETTE D; SMADJA C; FRANCO D;
Indirizzi:
HOP ANTOINE BECLERE,SERV CHIRURG GEN & DIGEST,GRP RECH CHIRURG FOIE &HYPERTENS PORTALE F-92141 CLAMART FRANCE HOP ANTOINE BECLERE,SERV CHIRURG GEN & DIGEST,GRP RECH CHIRURG FOIE &HYPERTENS PORTALE F-92141 CLAMART FRANCE
Titolo Testata:
Annales de chirurgie
fascicolo: 6, volume: 52, anno: 1998,
pagine: 543 - 546
SICI:
0003-3944(1998)52:6<543:TOIRAR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
FRE
Soggetto:
HEPATIC RESECTION; PROGNOSIS; SURGERY; MANAGEMENT; LIVER;
Keywords:
HEPATOCELLULAR CARCINOMA; 2ND HEPATIC RESECTION; TRANSARTERIAL CHEMOEMBOLIZATION; PERCUTANEOUS ETHANOL INJECTION THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M.S.S. Idrissi et al., "TREATMENT OF INTRAHEPATIC RECURRENCE AFTE R RESECTION OF HEPATOCELLULAR-CARCINOMA", Annales de chirurgie, 52(6), 1998, pp. 543-546

Abstract

Between October 1990 and December 1995, 86 patients underwent hepaticresection for hepatocellular carcinoma (HCC). All resections were carried out with the aim of achieving complete cure. Fifty one (60 %) of these patients subsequently developed recurrent HCC. Only twenty patients could be treated in our hospital. There were 18 men and 2 women, with a mean age of 61 years at the time of recurrence. Six patients hada normal liver. Fourteen patients had associated liver cirrhosis. Using Pugh's classification, 7 patients were Pugh A, 6 Pugh B and 1 Pugh C. The initial hepatic resection had consisted of major hepatectomy in9 cases and segmentectomy in the remaining 11 patients. The mean timeto recurrence was 17 months. There were 3 recurrences on the resection margin and 17 recurrences away from the hepatic stump. The therapeutic choice after hepatic recurrence was based on the number of tumors, hepatic function and the size of the liver remnant. Six patients were treated by tamoxifen due to poor hepatic function; median survival after recurrence was 6 months. Four patients with a single recurrent tumor on an atrophied liver remnant were treated by percutaneous ethanol injection with a median survival after recurrence of 15 months. Five patients with multiple diffuse lesions and good hepatic function were treated by transarterial chemoembolisation with a median survival after recurrence of 30 months. Five patients with a solitary tumor and good hepatic function underwent a second hepatic resection with a median survival after recurrence of 35 months. The overall median survival after diagnosis of recurrence was 20 months. These results suggest that anactive treatment should be carried our in cases of recurrence of HCC. A second resection, if technically possible, offers the best chance of survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 08:01:06