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Titolo:
EFFECT OF LUNG-VOLUME MAINTENANCE DURING SLEEP IN NOCTURNAL ASTHMA
Autore:
MARTIN RJ; PAK J; IRVIN CG;
Indirizzi:
NATL JEWISH CTR IMMUNOL & RESP MED,DEPT MED,1400 JACKSON ST,RM J116 DENVER CO 80206 UNIV COLORADO,HLTH SCI CTR,PULM & CRIT CARE SECT DENVER CO 80206
Titolo Testata:
Journal of applied physiology
fascicolo: 4, volume: 75, anno: 1993,
pagine: 1467 - 1470
SICI:
8750-7587(1993)75:4<1467:EOLMDS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHACHOLINE;
Keywords:
PULMONARY FUNCTION; BRONCHIAL RESPONSIVENESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Martin et al., "EFFECT OF LUNG-VOLUME MAINTENANCE DURING SLEEP IN NOCTURNAL ASTHMA", Journal of applied physiology, 75(4), 1993, pp. 1467-1470

Abstract

Previous studies have shown that lung volume decreases and airway resistance increases during sleep in patients with nocturnal asthma. To determine whether the fall in lung volume per se causes the overnight decrement in forced expiratory volume in 1 s (FEV1) and/or increase in bronchial responsiveness, we investigated the effect of preventing this nocturnal decrease in lung volume. The mean volume change on a baseline night was -16.3 +/- 1.6% from presleep values and on the volume maintenance night +7.1 +/- 3.0% (P = 0.0001). However, this maintenance of lung volume did not alter the overnight decrement in FEV1 (-29.6 +/- 5.2% baseline vs. -30.2 +/- 5.8% volume maintenance). Similarly, theincrease in bronchial responsiveness was also unaltered from baselineto volume maintenance nights, with presleep provocative concentrations of methacholine producing a 20% decrement in FEV1 of 0.28 +/- 0.15 vs. 0.22 +/- 0.7 mg/ml, respectively, and postsleep values of 0.07 +/- 0.03 vs. 0.04 +/- 0.02 mg/ml, respectively. Thus the fall in lung volume during sleep in the nocturnal asthmatic patient is a result, not a cause, of the overnight worsening of lung function.

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Documento generato il 05/07/20 alle ore 07:20:41