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Titolo:
AMPA RECEPTOR ACTIVATION POTENTIATED BY THE AMPA MODULATOR 1-BCP IS TOXIC TO CULTURED RAT HIPPOCAMPAL-NEURONS
Autore:
YAMADA KA;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT NEUROL,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PEDIAT ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,CTR STUDY NERVOUS SYST INJURY ST LOUIS MO 63110 ST LOUIS CHILDRENS HOSP,DEPT NEUROL ST LOUIS MO 63110
Titolo Testata:
Neuroscience letters
fascicolo: 2-3, volume: 249, anno: 1998,
pagine: 119 - 122
SICI:
0304-3940(1998)249:2-3<119:ARAPBT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DESENSITIZATION; CYCLOTHIAZIDE; EXCITOTOXICITY; S,S-DIOXIDE; COGNITION; CURRENTS; ISCHEMIA; DRUG;
Keywords:
BENZOYLPIPERIDINE; BENZOYLPYRROLIDINE; BENZOTHIADIAZINE; THIAZIDE; CYCLOTHIAZIDE; IDRA21; AMPAKINE; NOOTROPIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
K.A. Yamada, "AMPA RECEPTOR ACTIVATION POTENTIATED BY THE AMPA MODULATOR 1-BCP IS TOXIC TO CULTURED RAT HIPPOCAMPAL-NEURONS", Neuroscience letters, 249(2-3), 1998, pp. 119-122

Abstract

The benzoylpiperidine 1-(1,3-benzodioxol-5-ylcarbonyl)-piperidine (1-BCP), and related compounds, potentiate alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acidergic (AMPAergic) synaptic currents in central neurons, and improve performance of rodents and humans on learning and memory tasks. Their physiological actions are similar but not identical to thiazides, which also enhance AMPAergic synaptic responses and improve performance of rats in water-maze and passive- avoidance tests. Thiazides also dramatically increase AMPA receptor-mediated neuronal death in vitro and in vivo. Here it was evaluated whether 1-BCP potentiated AMPA receptor-mediated excitotoxicity in hippocampal neuroncultures. Glutamate + MK 801 (to block NMDA receptors) + 1 mM 1-BCP produced neuronal death that was reversed by 10 mu M -dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX), a selective AMPA receptor antagonist. 1-BCP and drugs with similar activities can facilitate AMPA receptor-mediated excitotoxicity. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 15:44:08