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Titolo:
EFFECT OF FOOD AND GENDER ON THE PHARMACOKINETICS OF TUCARESOL IN HEALTHY-VOLUNTEERS
Autore:
PECK RW; WOOTTON R; WIGGS R; LAYTON G; POSNER J;
Indirizzi:
GLAXO WELLCOME RES & DEV LTD,GREENFORD RD GREENFORD UB6 0HE MIDDX ENGLAND
Titolo Testata:
British journal of clinical pharmacology
fascicolo: 1, volume: 46, anno: 1998,
pagine: 83 - 86
SICI:
0306-5251(1998)46:1<83:EOFAGO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACODYNAMICS; AGENT;
Keywords:
FOOD; GENDER; HUMAN; INTERACTION; PHARMACOKINETICS; TUCARESOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Peck et al., "EFFECT OF FOOD AND GENDER ON THE PHARMACOKINETICS OF TUCARESOL IN HEALTHY-VOLUNTEERS", British journal of clinical pharmacology, 46(1), 1998, pp. 83-86

Abstract

Aims The potential effects of food and gender on the pharmacokineticsof tucaresol were investigated in healthy volunteers. Methods Ten males (mean weight 76.5 kg, age 27-42 years) and eight females (mean weight 58.9 kg, age 18-44 years) received a single oral dose of 200 mg tucaresol on two occasions in random order. On one occasion, tucaresol was given after an overnight fast and on the other, immediately after ingestion of a standard breakfast. Results There were no significant differences in standard pharmacokinetic parameters between the two occasions but the rate of tucaresol absorption was faster after food intake. Female subjects had higher C-max (ratio 1.25 with 95% CI 1.10-1.44) and AUC (ratio 1.25 with 95% CI 1.05-1.49) values than males but the differences were due to the higher body weights of the males; weight-adjusted apparent total clearance values (CL/F) were not different between genders (ratio 1.03 with 95% CI 0.87-1.21). Conclusions Food intake and gender have no significant effect on the exposure to orally administered tucaresol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:48:19