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Titolo:
INVOLVEMENT OF HUMAN CRM1 (EXPORTIN-1) IN THE EXPORT AND MULTIMERIZATION OF THE REX PROTEIN OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1
Autore:
HAKATA Y; UMEMOTO T; MATSUSHITA S; SHIDA H;
Indirizzi:
KYOTO UNIV,INST VIRUS RES KYOTO 606 JAPAN KYOTO UNIV,INST VIRUS RES KYOTO 606 JAPAN KUMAMOTO UNIV,SCH MED,DEPT INTERNAL MED 2 KUMAMOTO 860 JAPAN
Titolo Testata:
Journal of virology
fascicolo: 8, volume: 72, anno: 1998,
pagine: 6602 - 6607
SICI:
0022-538X(1998)72:8<6602:IOHC(I>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOMINANT-NEGATIVE MUTANTS; GENE-EXPRESSION REQUIRES; RNA RESPONSE ELEMENTS; HTLV-I REX; SEQUENCE REQUIREMENTS; NUCLEOLAR LOCALIZATION; REGULATORY PROTEINS; ACTIVATION DOMAIN; TRANS-ACTIVATOR; NUCLEAR EXPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
Y. Hakata et al., "INVOLVEMENT OF HUMAN CRM1 (EXPORTIN-1) IN THE EXPORT AND MULTIMERIZATION OF THE REX PROTEIN OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1", Journal of virology, 72(8), 1998, pp. 6602-6607

Abstract

We investigated the role of human CRM1 (hCRM1) (exportin 1) in the function of Rex protein encoded by human T-cell leukemia virus type 1. hCRM1 promoted the export of Rex protein from the nucleus to the cytoplasm. A Rex protein with a mutation in the activation domain, RexM90, lost both the ability to hind to hCRM1 and the ability to multimerize. The overexpression of hCRM1 complemented the functional defects of RexM64, which contains a mutation in the multimerization domain of Rex. Adominant-negative mutant of Rex which sequesters cofactors of Rex abrogated multimerization as well as the activity of the wild-type Rex protein. These two functions were simultaneously restored by the overexpression of hCRM1. Taken together, these results suggest that hCRM1 plays important roles in the multimerization and export of Rex protein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 20:14:45