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Titolo:
IMMUNOLOGICAL BACKGROUND OF POLYSACCHARID -PROTEIN-CONJUGATE VACCINATION
Autore:
MEYER M; GAHR M;
Indirizzi:
UNIV GOTTINGEN,KINDERKLIN,POSTFACH 3742-43 D-37070 GOTTINGEN GERMANY
Titolo Testata:
Monatsschrift fur Kinderheilkunde
fascicolo: 10, volume: 141, anno: 1993,
pagine: 770 - 776
SICI:
0026-9298(1993)141:10<770:IBOP-V>2.0.ZU;2-K
Fonte:
ISI
Lingua:
GER
Keywords:
POLYSACCHARIDE-PROTEIN-CONJUGATE VACCINATION; HAEMOPHILUS-INFLUENZAE; STREPTOCOCCUS PNEUMONIAE; TI-2 ANTIGEN; TD ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
M. Meyer e M. Gahr, "IMMUNOLOGICAL BACKGROUND OF POLYSACCHARID -PROTEIN-CONJUGATE VACCINATION", Monatsschrift fur Kinderheilkunde, 141(10), 1993, pp. 770-776

Abstract

Haemophilus influenzae and Streptococcus pneumoniae are bacteria witha polysaccharide capsule. The production of specific antibodies against capsular polysaccharide plays a pivotal role in the defence againstthese organisms. However, children under the age of two years do not at all or only poorly respond to an infection with encapsulated bacteria or after vaccination with purified capsular polysaccharide antigen. In contrast, protein antigens, e.g. tetanus- and diphtheriae-toxoid, are good immunogens in this age group. The difference between polysaccharide antigen and protein antigen is that the former are T-dependent antigens whereas the latter are T-independent. The reason for this agedependent ,,immunodeficiency'' is not clear. A functional immaturity of a B-cell population seems to be the reason for the unresponsivenessof young children against Ti-2 antigens. The Haemophilus conjugate vaccine contains the capsular polysaccharid chemically conjugated to a carrier protein. This results in an immune response against the polysaccharide with characteristics of a T dependent antigen, giving high immunogenicity even in children under the age of two years, resulting in high antibody-production and the induction of immunological memory.

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Documento generato il 29/11/20 alle ore 06:05:07