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Titolo:
PARALLEL LOSS OF PRESYNAPTIC AND POSTSYNAPTIC DOPAMINE MARKERS IN NORMAL AGING
Autore:
VOLKOW ND; WANG GJ; FOWLER JS; DING YS; GUR RC; GATLEY J; LOGAN J; MOBERG PJ; HITZEMANN R; SMITH G; PAPPAS N;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT MED UPTON NY 11973 BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794 UNIV PENN,SCH MED,DEPT PSYCHIAT,BRAIN BEHAV LAB PHILADELPHIA PA 19104
Titolo Testata:
Annals of neurology
fascicolo: 1, volume: 44, anno: 1998,
pagine: 143 - 147
SICI:
0364-5134(1998)44:1<143:PLOPAP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; HUMAN BRAIN; BINDING; PET; NEURONS; RATS; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
N.D. Volkow et al., "PARALLEL LOSS OF PRESYNAPTIC AND POSTSYNAPTIC DOPAMINE MARKERS IN NORMAL AGING", Annals of neurology, 44(1), 1998, pp. 143-147

Abstract

Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Positronemission tomography studies revealed that in healthy individuals, theage-related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. This association was specific for DA synaptic markers, because they were not correlatedwith striatal metabolism. Furthermore, the association was independent of age, suggesting that a common mechanism regulates the expression of receptors and transporters irrespective of age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:43:46