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Titolo:
THE EFFECT OF PENTAERITHRITYL-TETRANITRATE ON PARAMETERS OF THE MICROCIRCULATION
Autore:
BOHM C; HAUSTEIN KO;
Indirizzi:
FRIEDRICH SCHILLER UNIV,KLINIKUM,NORDHAUSER STR 78 D-99089 ERFURT GERMANY FRIEDRICH SCHILLER UNIV,KLINIKUM D-99089 ERFURT GERMANY
Titolo Testata:
International journal of clinical pharmacology and therapeutics
fascicolo: 7, volume: 36, anno: 1998,
pagine: 398 - 402
SICI:
0946-1965(1998)36:7<398:TEOPOP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTINUOUS THERAPY; BLOOD-FLOW; NITROGLYCERIN; TOLERANCE;
Keywords:
MICROCIRCULATION; HEALTHY SUBJECTS; GLYCEROL TRINITRATE; PENTAERITHRITYL TETRANITRATE; CAPILLARY ERYTHROCYTE VELOCITY; RED BLOOD CELL DEFORMABILITY; TRANSCUTANEOUS OXYGEN TENSION; PLASMA VISCOSITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
C. Bohm e K.O. Haustein, "THE EFFECT OF PENTAERITHRITYL-TETRANITRATE ON PARAMETERS OF THE MICROCIRCULATION", International journal of clinical pharmacology and therapeutics, 36(7), 1998, pp. 398-402

Abstract

Aim of the study: The effect of organic nitrates on microcirculation was first studied in 1964 and with regard to glyceroltrinitrate (GTN) an ''internal hemodilution'' (i.e. a fluid shift from the extravascular fluid to the intravascular compartment) was observed. Therefore, we found it of interest to study the effects of the long-acting PETN on parameters of hemorrheology. Methods. The effects of single doses of 25, 50, and 80 mg PETN, 0.4 mg GTN, and of placebo were investigated on the capillary erythrocyte velocity (CEV; Capiflow), the tissue oxygen tension (tcpO(2)), the deformability of red blood cells, the plasma viscosity and of the fibrin content of the plasma in a single-blind, randomized study over 12 h in 12 healthy female and male volunteers. The CEV and the tcpO(2) were measured in the nailfold of the fourth fingerand on the skin of its end phalanx, respectively. Statistical analysis was performed by analysis of variance, the calculation of epsilon (Greenhouse-Geisser), and the multiple t test. Results: After administration of 50 or 80 mg PETN the CEV decreased by 30% over a period of 2 or 4 h (p = 0.02 or 0.002). A decrease by 11% was measured 1 and 2 h after administration of GTN (p = 0.034). Under the same PETN doses tcpO(2) increased from 1.41 to 1.78 mm mercury (p = 0.002). The deformability of red blood cells was slightly increased after 50 and 80 mg PETN under share rates of 60 Pa from 55.5 to 58.0% 8 and 12 h after intake. The plasma viscosity was decreased after intake of 50 mg PETN 4 to 8 h(1.36 vs. 1.34 Pars, p = 0.023) and after intake of 80 mg 2 to 12 h post dose (1.36 vs. 1.33 Pars, p = 0.015). The systolic or diastolic blood pressure decreased, but was not significant. Conclusions: The PETN-induced decrease in CEV can be explained with the pre- and afterload decreasing properties of the nitrates. The increase in tcpO(2) and erythrocyte deformability and the decrease in viscosity are additional advantageous effects on the microcirculation. If the results are transferred from the nailfold of the finger to the myocardium, the benefit ofnitrates could not only be seen in the decrease in preload due to their vasodilating properties, but also in improving the parameters of microcirculation. The internal hemodilution and the slightly enhanced deformability might provide an additional supply of myocardial capillaries in case of myocardial ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 09:23:27