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Titolo:
A RABBIT MODEL OF HUMAN FAMILIAL, NONSYNDROMIC UNICORONAL SUTURE SYNOSTOSIS - II - INTRACRANIAL CONTENTS, INTRACRANIAL VOLUME, AND INTRACRANIAL-PRESSURE
Autore:
MOONEY MP; SIEGEL MI; BURROWS AM; SMITH TD; LOSKEN HW; DECHANT J; COOPER G; FELLOWSMAYLE W; KAPUCU MR; KAPUCU LO;
Indirizzi:
UNIV PITTSBURGH,DEPT ANAT & HISTOL,619 SALK HALL PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT ANTHROPOL PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT PLAST & RECONSTRUCT SURG PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT ORTHODONT PITTSBURGH PA 15261 UNIV PITTSBURGH,CLEFT PALATE CRANIOFACIAL CTR PITTSBURGH PA 15261 SLIPPERY ROCK UNIV,DEPT PHYS THERAPY SLIPPERY ROCK PA 16057 CHILDRENS HOSP,DEPT PEDIAT PLAST SURG PITTSBURGH PA 15213
Titolo Testata:
Child's nervous system
fascicolo: 6, volume: 14, anno: 1998,
pagine: 247 - 255
SICI:
0256-7040(1998)14:6<247:ARMOHF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNILATERAL CORONAL SYNOSTOSIS; MENTAL FUNCTION; CRANIAL VAULT; CRANIOSYNOSTOSIS; CHILDREN; PROGNOSIS; GROWTH;
Keywords:
PLAGIOCEPHALY; RABBIT MODEL; INTRACRANIAL PRESSURE; INTRACRANIAL VOLUME; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
M.P. Mooney et al., "A RABBIT MODEL OF HUMAN FAMILIAL, NONSYNDROMIC UNICORONAL SUTURE SYNOSTOSIS - II - INTRACRANIAL CONTENTS, INTRACRANIAL VOLUME, AND INTRACRANIAL-PRESSURE", Child's nervous system, 14(6), 1998, pp. 247-255

Abstract

This two-part study reviews data from a recently developed colony of New Zealand white rabbits with familial, nonsyndromic unilateral coronal suture synostosis, and this second pare presents neuropathological findings and age-related changes in intracranial volume (ICV) and intracranial pressure (ICP) in 106 normal rabbits and 56 craniosynostotic rabbits from this colony. Brain morphology and anteroposterior length were described in 44 rabbit fetuses and perinates (27 normal; 17 synostosed). Middle meningeal artery patterns were qualitatively assessed from 2-D PCC MRI VENC scans and endocranial tracings from 15, 126-day-old rabbits (8 normal, 7 rabbits with unicoronal synostosis). Brain metabolism was evaluated by assessing 18F-FDG uptake with high-resolutionPET scanning in 7, 25-day-old rabbits (3 normal, 4 with unicoronal orbicoronal synostosis). Intracranial contents and ICV were assessed using 3-D CT scanning of the skulls of 30 rabbits (20 normal,10 with unicoronal synostosis) at 42 and 126 days of age. Serial ICP data were collected from 66 rabbits (49 normal; 17 with unicoronal synostosis) at 25 and 42 days of age. ICP was assessed in the epidural space using a Codman NeuroMonitor microsensor transducer. Results revealed that cerebral cortex morphology was similar between normal and synostosed fetuses around the time of synostosis. Significantly (P<0.05) decreased A-Pcerebral hemisphere growth rates and asymmetrical cortical remodelingwere noted with increasing age in synostotic rabbits. In addition, rabbits with unicoronal suture synostosis exhibited asymmetrical middle meningeal artery patterns, decreased and asymmetrical brain metabolism, a ''beaten-copper'' intracranial appearance, significantly (P<0.05) decreased ICV, and significantly (P<0.01) elevated ICP compared with normal control rabbits. The advantages and disadvantages of these rabbits as a model for human familial, nonsyndromic unicoronal suture synostosis are discussed, especially in light of recent clinical neuropathological, ICV, and ICP findings recorded in human craniosynostotic studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:12:19