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Titolo:
QUANTITATION OF LUNG ELASTIN AND COLLAGEN IN PROTEIN AND ESSENTIAL FATTY-ACID MALNOURISHED RATS
Autore:
BLANKENSHIP JW; MCKINNEY BC; ROOS PJ; SANDBERG LB;
Indirizzi:
LOMA LINDA UNIV,DEPT NUTR LOMA LINDA CA 92350 LOMA LINDA UNIV,DEPT PATHOL LOMA LINDA CA 92350 LOMA LINDA UNIV,DEPT BIOCHEM LOMA LINDA CA 92350 JERRY L PETTIS MEM VET ADM MED CTR,CONNECT TISSUE LAB LOMA LINDA CA 92357
Titolo Testata:
Connective tissue research
fascicolo: 4, volume: 29, anno: 1993,
pagine: 311 - 318
SICI:
0300-8207(1993)29:4<311:QOLEAC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTNATAL-DEVELOPMENT; DEFICIENCY;
Keywords:
ELASTIN; COLLAGEN; LUNG; PROTEIN DEFICIENCY; ESSENTIAL FATTY ACID DEFICIENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Blankenship et al., "QUANTITATION OF LUNG ELASTIN AND COLLAGEN IN PROTEIN AND ESSENTIAL FATTY-ACID MALNOURISHED RATS", Connective tissue research, 29(4), 1993, pp. 311-318

Abstract

Thirty-nine 40-day old male Sprague-Dawley rats (average wt. 115g) were divided into 4 groups and fed diets A, control; B, essential fatty acid (EFA) deficient; C, protein deficient; D, combined protein and EFA deficient. At the end of 5 weeks, lungs were removed from the animals for collagen and elastin quantitation and for morphometric measurements. The collagen content of the lungs which ranged from 95-100 mug/mgdried fat-free (D.F.F.) tissue, was not altered by protein or EFA deficiencies. The elastin content of lungs was markedly increased in diets C and D while the cross-linking (Isodesmosine-desmosine content) expressed as residues per 1,000 (R/1000) was not different in the four groups. The elastin content of lungs from group D animals was greater than group C suggesting an additive effect from the EFA deficiency in diet D. The morphometric measurements indicated no change in alveolar linear diameter (L(m)) while the total alveolar surface area (ISA(AlV)) was decreased by the deficient diets C and D. The protein deficiency and the combined protein and EFA deficiencies produced an increased elastin content in lung. Elastin cross-linking and collagen quantity was not affected by the dietary treatments. The morphometric measurements indicated that protein deficiency in these animals did not produce structural changes in the lungs as indicated by alveolar dimensions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:03:00