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Titolo:
PHARMACOLOGICAL CHARACTERIZATION OF NICOTINIC RECEPTOR-MEDIATED ACETYLCHOLINE-RELEASE IN RAT-BRAIN - AN IN-VIVO MICRODIALYSIS STUDY
Autore:
TANI Y; SAITO K; IMOTO M; OHNO T;
Indirizzi:
SUNTORY INST BIOMED RES,1-1-1 WAKAYAMADAI SHIMAMOTO OSAKA 618 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 2, volume: 351, anno: 1998,
pagine: 181 - 188
SICI:
0014-2999(1998)351:2<181:PCONRA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-)H-3>METHYLCARBAMYLCHOLINE BINDING-SITES; SHORT-TERM-MEMORY; ALZHEIMERS-DISEASE; ANXIOLYTIC ACTIVITIES; (S)-3-METHYL-5-(1-METHYL-2-PYRROLIDINYL)ISOXAZOLE ABT-418; FUNCTIONAL EXPRESSION; HIPPOCAMPAL-NEURONS; CHOLINERGIC LIGAND; CHANNEL; SYNAPTOSOMES;
Keywords:
NICOTINIC RECEPTOR; ACETYLCHOLINE RELEASE; MICRODIALYSIS; ABT-418; GTS-21; DIHYDRO-BETA-ERYTHROIDINE; METHYLLYCACONITINE; BRAIN; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
Y. Tani et al., "PHARMACOLOGICAL CHARACTERIZATION OF NICOTINIC RECEPTOR-MEDIATED ACETYLCHOLINE-RELEASE IN RAT-BRAIN - AN IN-VIVO MICRODIALYSIS STUDY", European journal of pharmacology, 351(2), 1998, pp. 181-188

Abstract

In vivo microdialysis was used to investigate nicotinic receptor-mediated acetylcholine release in the hippocampus, frontal cortex, and striatum of freely moving rats. Intraperitoneal administration of (-)-nicotine increased the release of acetylcholine in the hippocampus and frontal cortex but not in the striatum, (-)-Nicotine exhibited a bell-shaped dose-response relationship, and showed attenuation of response atthe highest dose (5.0 mg/kg i.p.) in both the hippocampus and frontalcortex. In the hippocampus, (-)-nicotine (1.0 mg/kg i.p.)-induced increase of acetylcholine release was blocked by pretreatment with the centrally acting nicotinic receptor channel blocker, mecamylamine (1.0 mg/kg i.p.), but not by hexamethonium (5.0 mg/kg i.p.), suggesting thatthe effects of (-)-nicotine were mediated by the central nicotinic receptor. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT-418, 1.0 and 5.0 mg/kg i.p.), reported to be a selective agonist for alpha 4 beta 2 nicotinic receptor subunits, also enhanced the release of acetylcholine in the hippocampus, while 3-(2,4-dimethoxybenzlidene)-anabaseine (GTS-21, 1.0 and 5.0 mg/kg i.p.), which has high affinity for the alpha 7 nicotinic receptor subunit, was without effect. The natural alkaloids isolated from plants, (-)-cytisine and(-)-lobeline, had littleeffect on acetylcholine release from the hippocampus. A competitive antagonist for alpha 4 beta 2 subunits of the nicotinic receptor, dihydro-beta-erythroidine, and a partial agonist for the beta 2 subunit-containing nicotinic receptor, (-)-cytisine, inhibited (-)-nicotine-induced increase of acetylcholine release from the hippocampus, whereas a selective antagonist for the alpha 7 subunit, methyllycaconitine, and apartial agonist for the alpha 3 subunit-containing nicotinic receptor, (-)-lobeline, did not. These results indicate that there are certaindifferences among brain regions in the response of nicotinic receptor-mediated acetylcholine release and that (-)-nicotine-induced acetylcholine release in the rat hippocampus may be attributed to activation of the alpha 4 beta 2 nicotinic receptor subunits. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 11:38:46