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Titolo:
ENDOTHELIUM-DEPENDENT VASODILATION OF THE SKIN MICROCIRCULATION IN HEART-TRANSPLANT RECIPIENTS
Autore:
ANDREASSEN AK; GULLESTAD L; HOLM T; SIMONSEN S; KVERNEBO K;
Indirizzi:
UNIV OSLO,RIKSHOSP,DEPT MED B N-0027 OSLO NORWAY UNIV OSLO,RIKSHOSP,DEPT CARDIOL N-0027 OSLO NORWAY
Titolo Testata:
Clinical transplantation
fascicolo: 4, volume: 12, anno: 1998,
pagine: 324 - 332
SICI:
0902-0063(1998)12:4<324:EVOTSM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORTHOTOPIC CARDIAC TRANSPLANTATION; LASER DOPPLER FLOWMETER; TISSUE BLOOD-FLOW; NITRIC-OXIDE; CYCLOSPORINE-A; SODIUM-NITROPRUSSIDE; RESISTANCE ARTERIES; VASCULAR-RESPONSES; FAILURE; ACETYLCHOLINE;
Keywords:
HEART TRANSPLANTATION; MICROCIRCULATION; ENDOTHELIUM-DEPENDENT VASODILATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Andreassen et al., "ENDOTHELIUM-DEPENDENT VASODILATION OF THE SKIN MICROCIRCULATION IN HEART-TRANSPLANT RECIPIENTS", Clinical transplantation, 12(4), 1998, pp. 324-332

Abstract

Patients with heart failure demonstrate attenuated endothelium-dependent vasodilation of the peripheral circulation. while this is suggested to be reversed after heart transplantation. However, data from humansubjects are limited and conflict with studies on the peripheral vasomotor tone in cyclosporine-treated animals, suggesting endothelial dysfunction. We recorded forearm skin perfusion responses following graded iontophoresis of 1% acetylcholine (endothelium-dependent) and 1% sodium nitroprusside (endothelium-independent) by laser Doppler perfusionmeasurements in 32 heart transplant recipients and 15 age-matched controls. III addition, the hyperemic response to 3 min of blood flow occlusion to the forearm was measured on the third finger pulp. With comparable baseline values, the increases in perfusion to the 4 applications of acetylcholine were significantly attenuated in heart transplant recipients compared with controls: 59 +/- 9 vs. 146 +/- 32, 242 +/- 39vs. 492 +/- 77, 450 +/- 66 vs. 845 +/- 120 and 699 +/- 77 vs. 993 +/-139% (mean +/- SEM; all p < 0.01). Peak hyperemia (134 +/- 4 vs. 153 /- 12 arbitrary units (AU); p < 0.05), time for the hyperemic perfusion to return to preocclusive baseline (52.4 vs. 102.9 s; p < 0.01) andhence the area under the perfusion curve (1469 +/- 244 vs. 4581 +/- 921 AU s; p < 0.01) were reduced among heart transplant recipients. Thearea under the perfusion curve correlated significantly, with mean arterial blood pressure (r = - 0.60, p < 0.01) and with the responses toiontophoresis of acelylcholine (r = 0.41 p < 0.01), Two non-invasive tests of vascular function demonstrate attenuated endothelial-dependent microvascular responses in heart transplant recipients. The relativeimpact of prior congestive heart failure and postoperative factors, such as treatment with cyclosporine. remains to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:49:44