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Titolo:
NEUROBIOLOGY OF LITHIUM - AN UPDATE
Autore:
LENOX RH; MCNAMARA RK; PAPKE RL; MANJI HK;
Indirizzi:
UNIV FLORIDA,COLL MED,DEPT PSYCHIAT,POB 100256 GAINESVILLE FL 32610 UNIV FLORIDA,COLL MED,DEPT PHARMACOL GAINESVILLE FL 32610 UNIV FLORIDA,COLL MED,DEPT NEUROSCI GAINESVILLE FL 32610 WAYNE STATE UNIV,SCH MED,DEPT PSYCHIAT BEHAV NEUROSCI & PHARMACOL DETROIT MI 00000
Titolo Testata:
The Journal of clinical psychiatry
, volume: 59, anno: 1998, supplemento:, 6
pagine: 37 - 47
SICI:
0160-6689(1998)59:<37:NOL-AU>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; STIMULATED ADENYLATE-CYCLASE; GAMMA-AMINOBUTYRIC-ACID; IMMORTALIZED HIPPOCAMPAL CELLS; ENDOGENOUS ADP-RIBOSYLATION; RECEPTOR SUPER-SENSITIVITY; BIPOLAR AFFECTIVE-DISORDER; CYCLIC-AMP ACCUMULATION; CEREBRAL-CORTEX SLICES; RAT CORPUS STRIATUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
180
Recensione:
Indirizzi per estratti:
Citazione:
R.H. Lenox et al., "NEUROBIOLOGY OF LITHIUM - AN UPDATE", The Journal of clinical psychiatry, 59, 1998, pp. 37-47

Abstract

Lithium remains a first-line approach for the treatment of acute mania and the prophylactic management of manic-depressive illness, yet theunderlying neurobiological mechanisms remain as yet undefined. In this paper we critically examine the accumulated preclinical and clinicalevidence for the action of lithium in the brain and suggest areas that may be most productive for future investigation, i.e., membrane transport systems, neurotransmitter receptor regulation, second messenger generating systems, protein kinase C (PKC) regulation, and gene expression. In their experimental design, preclinical investigations have often jeopardized the physiologic relevance of their studies by a relative lack of attention to issues such as therapeutic concentrations, acute versus chronic exposure, and a lack of adequate cation and/or psychotropic controls. Future studies should account for the established prophylactic efficacy of lithium, the higher risk for relapse into maniaafter abrupt discontinuation, the ability of lithium to stabilize recurrent depression associated with unipolar disorder? and the efficacy of lithium in the treatment of refractory major depressive disorder inthe presence of an antidepressant. Studies of the action of lithium in receptor mediated phosphoinositide signaling in the brain over the past several years have opened up heuristic lines of investigation thatstem from lithium's uncompetitive inhibition of the enzyme inositol monophosphatase. Subsequent studies involving regulation of inositol transport, PKC isozymes and activity, and the expression of the major PKC substrate MARCKS (myristoylated alanine-rich C-kinase substrate) have offered potential avenues for understanding the complexity of the action of long-term lithium in the brain. These studies will offer us a better understanding of the neuroanatomical sites of action of lithiumand together with ongoing clinical investigations using brain imagingin patients with manic-depressive illness a more complete understanding of the pathophysiology of this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:42:50