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Titolo:
POTENTIOMETRIC AND NMR SPECTROSCOPIC STUDY OF PROTONATIONS AND AMIDE HYDROGEN-EXCHANGE RATES OF DTPA-BIS(BUTYLAMIDE), DTPA-BIS(GLUCAMIDE), AND THEIR LANTHANIDE(III) COMPLEXES
Autore:
LAMMERS H; VANDERHEIJDEN AM; VANBEKKUM H; GERALDES CFGC; PETERS JA;
Indirizzi:
DELFT UNIV TECHNOL,LAB ORGAN CHEM & CATALYSIS,JULIANALAAN 136 NL-2628BL DELFT NETHERLANDS DELFT UNIV TECHNOL,LAB ORGAN CHEM & CATALYSIS NL-2628 BL DELFT NETHERLANDS UNIV COIMBRA,FAC SCI,DEPT BIOCHEM P-3000 COIMBRA PORTUGAL UNIV COIMBRA,CTR NEUROSCI P-3000 COIMBRA PORTUGAL
Titolo Testata:
Inorganica Chimica Acta
fascicolo: 2, volume: 277, anno: 1998,
pagine: 193 - 201
SICI:
0020-1693(1998)277:2<193:PANSSO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; METAL-COMPLEXES; STABILITY-CONSTANTS; AQUEOUS-SOLUTION; CONTRAST AGENTS; CHEMICAL-SHIFTS; AMINO-ACIDS; RELAXATION; THERMODYNAMICS; DYNAMICS;
Keywords:
MRI CONTRAST AGENTS; LANTHANIDE COMPLEXES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
H. Lammers et al., "POTENTIOMETRIC AND NMR SPECTROSCOPIC STUDY OF PROTONATIONS AND AMIDE HYDROGEN-EXCHANGE RATES OF DTPA-BIS(BUTYLAMIDE), DTPA-BIS(GLUCAMIDE), AND THEIR LANTHANIDE(III) COMPLEXES", Inorganica Chimica Acta, 277(2), 1998, pp. 193-201

Abstract

The macroscopic and microscopic protonations of DTPA-GlucA(2) (DTPA-bis(glucamide)) have been investigated using potentiometry, H-1 and C-13 NMR. The protonation behavior appears to be similar to that of the corresponding bis(alkylamides), showing that it is not affected by the presence of the polyhydroxy side chains. Consideration of the various possible protonation pathways leads to the conclusion that the differences in basicity of the amino functions in DTPA and DTPA-bis( amides) result in different protonation sequences of these ligands, which is reflected in the macroscopic protonation constants. The significance for the design of DTPA-based contrast agents for MRI is discussed. Exchange rates of the amide NH of this compound and that of DTPA-bis(butylamide) (DTPA-BuA(2)) were determined via longitudinal relaxation rate measurements of the amide H-1 resonances in H2O-D2O (9:1) as solvent. The reaction is strongly base catalyzed and the rate increases substantially upon coordination of the DTPA-bis(amide) by La(III). (C) 1998 Elsevier Science S.A. All rights reserved.

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Documento generato il 28/11/20 alle ore 09:31:55