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Titolo:
SPONTANEOUS INTRACEREBRAL HEMORRHAGE REVEALING ADDISONS-DISEASE
Autore:
DEREX L; GIRAUD P; HANSS M; RICHE H; NIGHOGHOSSIAN N; TROUILLAS P;
Indirizzi:
HOP NEUROL,SERV URGENCES CEREBROVASC,59 BLVD PINEL F-69003 LYON FRANCE HOP CARDIOL,SERV HEMATOL & CYTOGENET LYON FRANCE HOP NEUROL,SERV REANIMAT & SOINS INTENS POSTOPERATOIRES LYON FRANCE
Titolo Testata:
Cerebrovascular diseases
fascicolo: 4, volume: 8, anno: 1998,
pagine: 240 - 243
SICI:
1015-9770(1998)8:4<240:SIHRA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM-CHOLESTEROL; STROKE; PROGRAM;
Keywords:
INTRACEREBRAL HEMORRHAGE; ADDISONS DISEASE; HEPATOCELLULAR FIBRINOGEN SYNTHESIS; VITAMIN K DEFICIENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
L. Derex et al., "SPONTANEOUS INTRACEREBRAL HEMORRHAGE REVEALING ADDISONS-DISEASE", Cerebrovascular diseases, 8(4), 1998, pp. 240-243

Abstract

We report a case of spontaneous intracerebral hemorrhage occurring ina young woman and revealing Addison's disease. This autoimmune primary adrenocortical insufficiency was associated with premature ovarian failure. Exhaustive research for nonhypertensive causes of intracerebral hemorrhage was negative. Initial coagulation studies disclosed severe hypofibrinogenemia and prolonged prothrombin time related to vitaminK-dependent coagulation factor deficit. Clotting abnormalities cleared at 4 months under treatment with hydrocortisone. Glucocorticoids arepotent regulators of fibrinogen biosynthesis, increasing fibrinogen secretion. We conclude that primary adrenocortical insufficiency induced this hemorrhagic diathesis leading to spontaneous intracerebral hemorrhage. This latter has never been reported in Addison's disease. Primary adrenocortical insufficiency should be considered as a rare potential cause of nonhypertensive intracerebral hemorrhage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 12:30:10