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Titolo:
MICROEMBOLIC LOAD IN ASYMPTOMATIC PATIENTS WITH CARDIAC ANEURYSM, SEVERE VENTRICULAR DYSFUNCTION, AND ATRIAL-FIBRILLATION - CLINICAL AND HEMORHEOLOGICAL CORRELATES
Autore:
NABAVI DG; ARATO S; DROSTE DW; SCHULTEALTEDORNEBURG G; KEMENY V; REINECKE H; BORGGREFE M; BREITHARDT G; RINGELSTEIN EB;
Indirizzi:
UNIV MUNSTER,DEPT NEUROL,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY UNIV MUNSTER,DEPT CARDIOL & ANGIOL D-48129 MUNSTER GERMANY
Titolo Testata:
Cerebrovascular diseases
fascicolo: 4, volume: 8, anno: 1998,
pagine: 214 - 221
SICI:
1015-9770(1998)8:4<214:MLIAPW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTENSITY TRANSIENT SIGNALS; CEREBRAL EMBOLIC SIGNALS; CAROTID-ARTERY STENOSIS; TRANSCRANIAL DOPPLER; MYOCARDIAL-INFARCTION; HEART-FAILURE; STROKE; DISEASE; ANTICOAGULATION; PREVALENCE;
Keywords:
COAGULATION; DIAGNOSTIC ULTRASONOGRAPHY; EMBOLISM; HEMORHEOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
D.G. Nabavi et al., "MICROEMBOLIC LOAD IN ASYMPTOMATIC PATIENTS WITH CARDIAC ANEURYSM, SEVERE VENTRICULAR DYSFUNCTION, AND ATRIAL-FIBRILLATION - CLINICAL AND HEMORHEOLOGICAL CORRELATES", Cerebrovascular diseases, 8(4), 1998, pp. 214-221

Abstract

Transcranial Doppler sonography has become a widely used method for detecting cerebral circulating microemboli (ME) arising from the carotid arteries or the heart. Yet, studies on subgroups of patients with distinct cardiac sources of embolism are still limited. The same holds true for investigations on the relationship between microembolization and hemorheological parameters. A total of 142 patients suffering from left ventricular aneurysm (LVA, n = 52), severe left ventricular dysfunction (LVD, n = 43), or chronic atrial fibrillation (AF, n = 47) wereenrolled in this study. All patients had been neurologically asymptomatic for at least 1 month. Further relevant embolic disorders of the carotid arteries and the heart had been excluded. Unilateral monitoringfor ME over the middle cerebral artery was performed for 30 min. Blood was drawn after each monitoring for determination of plasmatic coagulation parameters, as well as plasma viscosity, and platelet reactivity. The overall prevalence of ME was 31%, with a slightly higher prevalence in patients with LVA (37%) compared to patients suffering from AF(30%) or LVD (26%). With single-factor analysis, a trend towards higher ME prevalences was found with (a) a history of remote embolic events, (b) ineffective anticoagulation, (c) increased platelet aggregation, or (d) increased plasma viscosity (all p > 0.1). The combination of ineffective anticoagulation in conjunction with increased platelet aggregation, however, was significantly associated with higher ME rates even after adjustment for other factors by logistic regression analysis. Our results demonstrate a low ongoing microembolic activity in asymptomatic patients suffering from LVA, LVD and AF. An activated plasmatic coagulation system together with increased platelet aggregation contributes to ME generation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:16:58