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Titolo:
NEUROPEPTIDE-Y RECEPTOR-1 (NPY-Y1) EXPRESSION IN HUMAN HEART-FAILURE AND HEART-TRANSPLANTATION
Autore:
GULLESTAD L; AASS H; ROSS H; UELAND T; GEIRAN O; KJEKSHUS J; SIMONSEN S; FOWLER M; KOBILKA B;
Indirizzi:
STANFORD UNIV,SCH MED,HOWARD HUGHES MED INST,300 PASTEUR DR STANFORD CA 94305 STANFORD UNIV,SCH MED,HOWARD HUGHES MED INST STANFORD CA 94305 UNIV HOSP,RIKSHOSP N-0027 OSLO NORWAY
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 1-2, volume: 70, anno: 1998,
pagine: 84 - 91
SICI:
0165-1838(1998)70:1-2<84:NR(EIH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL CATECHOLAMINE; FUNCTIONAL EXPRESSION; CARDIAC-HYPERTROPHY; MECHANISMS; PEPTIDE; GENE; SUPERSENSITIVITY; CLONING;
Keywords:
HEART FAILURE; HEART TRANSPLANTATION; BETA-ADRENOCEPTORS; BETA-ACTIN; Y1 MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
L. Gullestad et al., "NEUROPEPTIDE-Y RECEPTOR-1 (NPY-Y1) EXPRESSION IN HUMAN HEART-FAILURE AND HEART-TRANSPLANTATION", Journal of the autonomic nervous system, 70(1-2), 1998, pp. 84-91

Abstract

Neuropeptide Y (NPY) is a neurotransmitter released from cardiac sympathetic nerve terminals along with catecholamines. It influences vascular tone and cardiac function, probably through the receptor subtype Y1. The present study examined the expression of Y1 in patients with end-stage heart failure and in heart transplant recipients. Y1 mRNA was analyzed in right ventricular endomyocardial biopsies taken from 12 donor hearts prior to implantation (controls), 15 patients with end stage heart failure at time of transplantation, and 16 patients more than 1 year after transplantation. RT-PCR (reverse transcription polymerasechain reaction) was used to detect mRNA for the Y1 receptor, the beta(1)-adrenergic-receptor, and beta-actin. yr mRNA was present in biopsies of all donor hearts, but was observed significantly less frequentlyin the two patient groups; only 5 out of 15 (P < 0.01) heart failure and 9 out of 16 (P < 0.05) transplant recipients demonstrated visible PCR product. In contrast, mRNA for the beta(1)-adrenergic receptor andbeta-actin were detected by RT-PCR in all samples. Our results provide the first evidence for altered regulation of the neuropeptide YZ receptor in heart failure and transplant patients, and suggests that lossof signal transduction by this receptor may be adaptive in both groups. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:52:55