Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE ROLE OF PURINERGIC AND ADRENERGIC TRANSMITTERS OF THE SYMPATHETICSYSTEM IN THE CONTROL OF ARTERIAL BLOOD-PRESSURE VARIABILITY
Autore:
TARASOVA OS; GOLUBINSKAYA VO; KOSIAKOV AN; BOROVIK AS; TIMIN EN; RODIONOV IM;
Indirizzi:
MOSCOW MV LOMONOSOV STATE UNIV,FAC BIOL,DEPT HUMAN & ANIM PHYSIOL,VOROBIOV HILLS MOSCOW 119899 RUSSIA MOSCOW MV LOMONOSOV STATE UNIV,FAC BIOL,DEPT HUMAN & ANIM PHYSIOL MOSCOW 119899 RUSSIA AV VISHNEVSKII SURG INST MOSCOW 113811 RUSSIA
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 1-2, volume: 70, anno: 1998,
pagine: 66 - 70
SICI:
0165-1838(1998)70:1-2<66:TROPAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINOAORTIC DEAFFERENTATION; HEART-RATE; RESPONSES; DENERVATION; LABILITY; PPADS;
Keywords:
ADENOSINE BIPHOSPHATE; ARTERIAL BARORECEPTORS; BLOOD PRESSURE VARIABILITY; ALPHA,BETA-METHYLENE ADENOSINE TRIPHOSPHATE; PPADS; SYMPATHETIC NERVOUS SYSTEM; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
O.S. Tarasova et al., "THE ROLE OF PURINERGIC AND ADRENERGIC TRANSMITTERS OF THE SYMPATHETICSYSTEM IN THE CONTROL OF ARTERIAL BLOOD-PRESSURE VARIABILITY", Journal of the autonomic nervous system, 70(1-2), 1998, pp. 66-70

Abstract

Variability of mean arterial pressure (MAP) was examined in chronically instrumented, conscious, freely moving rats with pharmacologically altered efferent sympathetic influences on the cardiovascular system. MAP was recorded for 30 min beat-to-beat, using a computer under both control and experimental conditions: after administration of adrenoceptor antagonists (prazosin or phentolamine) or under P2X receptor inactivation produced either by desensitization with alpha,beta-methylene ATP or by PPADS blockade. Inhibition of adrenergic sympathetic effects on the cardiovascular system produced long-lasting and stable decreasein MAP. Prazosin did not modify MAP variability whereas phentolamine enhanced it. Under P2X receptor desensitization MAP decreased, the hypotensive effect being accompanied by a significant increase in MAP variability. A similar increase in MAP variability was observed after PPADS administration, while MAP level was not changed. Administration of PPADS in combination with phentolamine increased MAP variability more significantly than each of the drugs given separately. Changes in MAP variability under the various experimental conditions were not consistently correlated with changes in heart rate variability. We propose that ATP, being a mediator of sympathetic vasoconstriction, participatesin baroreceptor-induced stabilization of MAP level. (C) 1998 ElsevierScience B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:13:59