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Titolo:
A THEORETICAL-STUDY OF SURFACTANT AND LIQUID DELIVERY INTO THE LUNG
Autore:
HALPERN D; JENSEN OE; GROTBERG JB;
Indirizzi:
UNIV ALABAMA,DEPT MATH TUSCALOOSA AL 35487 UNIV ALABAMA,DEPT MATH TUSCALOOSA AL 35487 UNIV CAMBRIDGE,DEPT APPL MATH & THEORET PHYS CAMBRIDGE CB3 9EW ENGLAND NORTHWESTERN UNIV,DEPT BIOMED ENGN EVANSTON IL 60208 NORTHWESTERN UNIV,SCH MED,DEPT ANESTHESIOL CHICAGO IL 60611
Titolo Testata:
Journal of applied physiology (1985)
fascicolo: 1, volume: 85, anno: 1998,
pagine: 333 - 352
SICI:
8750-7587(1998)85:1<333:ATOSAL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; FLUID-ELASTIC INSTABILITIES; LINED FLEXIBLE TUBES; THIN VISCOUS FILM; EXOGENOUS SURFACTANT; PULMONARY SURFACTANT; RABBIT LUNGS; SYNTHETIC SURFACTANT; SEMIINFINITE BUBBLE; SOLUBLE SURFACTANT;
Keywords:
PULMONARY SURFACTANT; DRUG DELIVERY; SURFACTANT REPLACEMENT THERAPY; RESPIRATORY DISTRESS SYNDROME; MARANGONI FLOW; AIRWAY LIQUID; SURFACE TENSION DYNAMICS; PULMONARY FLUID MECHANICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
D. Halpern et al., "A THEORETICAL-STUDY OF SURFACTANT AND LIQUID DELIVERY INTO THE LUNG", Journal of applied physiology (1985), 85(1), 1998, pp. 333-352

Abstract

A computational study is presented for the transport of liquids and insoluble surfactant through the lung airways, delivered from a source at the distal end of the trachea. Four distinct transport regimes are considered: 1) the instilled bolus may create a liquid plug that occludes the large airways but is forced peripherally during mechanical ventilation; 2) the bolus creates a deposited film on the airway walls, either from the liquid plug transport or from direct coating, that drains under the influence of gravity through the first few airway generations; 3) in smaller airways, surfactant species form a surface layer that spreads due to surface-tension gradients, i.e., Marangoni flows; and 4) the surfactant finally reaches the alveolar compartment where itis cleared according to first-order kinetics. The time required for aquasi-steady-state transport process to evolve and for the subsequentdelivery of the dose is predicted. Following fairly rapid transients,on the order of seconds, steady-state transport develops and is governed by the interaction of Marangoni flow and alveolar kinetics. Total delivery time is similar to 24 h for a typical first dose. Numerical solutions show that both transit and delivery times are strongly influenced by the strength of the preexisting surfactant and the geometric properties of the airway network. Delivery times for follow-up doses can increase significantly as the level of preexisting surfactant rises.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:18:15