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Titolo:
IGA NEPHROPATHY COMPLICATING DIABETIC GLOMERULOSCLEROSIS
Autore:
ORFILA C; LEPERT JC; MODESTO A; PIPY B; SUC JM;
Indirizzi:
CHU RANGUEIL,UPS EA 2405 F-31403 TOULOUSE 4 FRANCE CHU RANGUEIL,SERV NEPHROL F-31403 TOULOUSE 4 FRANCE
Titolo Testata:
Nephron
fascicolo: 3, volume: 79, anno: 1998,
pagine: 279 - 287
SICI:
0028-2766(1998)79:3<279:INCDG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC MEMBRANOUS GLOMERULONEPHRITIS; NONDIABETIC RENAL-DISEASE; HENOCH-SCHONLEIN PURPURA; GLOMERULAR-DISEASES; NEPHROTIC SYNDROME; IMMUNE-COMPLEXES; MELLITUS; PATIENT; LESIONS; PREVALENCE;
Keywords:
IMMUNOGLOBULIN A NEPHROPATHY; DIABETES; GLOMERULOSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
C. Orfila et al., "IGA NEPHROPATHY COMPLICATING DIABETIC GLOMERULOSCLEROSIS", Nephron, 79(3), 1998, pp. 279-287

Abstract

A retrospective study was done on 66 diabetic patients who had renal biopsies performed during 1979-1994. This review shows 10 patients whopresented IgA nephropathy associated with diabetic nephropathy. Six patients had insulin-dependent diabetes mellitus and 4 patients non-insulin-dependent diabetes mellitus. All patients presented with proteinuria and 7 had hematuria. Four patients presented with renal impairment. Histologic evaluation disclosed the presence of thickened glomerularbasement membranes and increased mesangial matrix in all cases, associated with nodular sclerosis in 8 cases. By immunofluorescence, diffuse mesangial IgA deposits were observed in all cases. The high incidence of the coexistence of IgA nephropathy and diabetes seems not merely coincidental. Structural and/or functional abnormalities of the glomerular basement membranes might facilitate the development of immune complex glomerular diseases. In patients with diabetes, the appearance ofurinary abnormalities and/or deterioration in renal function altered the clinical history of diabetic nephropathy. The disorders are clinically suggestive of the presence of nondiabetic renal disease and raised the possibility of another pathogenetic mechanism.

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Documento generato il 03/12/20 alle ore 21:51:05