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Titolo:
LOCAL AND SYSTEMIC ISOTYPE-SPECIFIC ANTIBODY-RESPONSES TO EQUINE INFLUENZA-VIRUS INFECTION VERSUS CONVENTIONAL VACCINATION
Autore:
NELSON KM; SCHRAM BR; MCGREGOR MW; SHEORAN AS; OLSEN CW; LUNN DP;
Indirizzi:
UNIV WISCONSIN,SCH VET MED,DEPT MED SCI,2015 LINDEN DR W MADISON WI 53706 UNIV WISCONSIN,SCH VET MED,DEPT MED SCI MADISON WI 53706 UNIV WISCONSIN,SCH VET MED,DEPT PATHOBIOL SCI MADISON WI 53706 UNIV KENTUCKY,GLUCK EQUINE RES CTR,DEPT VET SCI LEXINGTON KY 40546
Titolo Testata:
Vaccine
fascicolo: 13, volume: 16, anno: 1998,
pagine: 1306 - 1313
SICI:
0264-410X(1998)16:13<1306:LASIAT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
IGG SUBCLASS RESPONSES; RESPIRATORY-TRACT; IMMUNOGLOBULIN-A; INTRACELLULAR NEUTRALIZATION; MONOCLONAL-ANTIBODIES; IMMUNE-RESPONSES; PASSIVE TRANSFER; HEMAGGLUTININ; PROTECTION; VACCINES;
Keywords:
HORSES; INFLUENZA VIRUS; MUCOSAL IMMUNITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
K.M. Nelson et al., "LOCAL AND SYSTEMIC ISOTYPE-SPECIFIC ANTIBODY-RESPONSES TO EQUINE INFLUENZA-VIRUS INFECTION VERSUS CONVENTIONAL VACCINATION", Vaccine, 16(13), 1998, pp. 1306-1313

Abstract

Inactivated alum-adjuvanted conventional equine influenza virus vaccines are of pool efficacy and offer limited short-term protection against infection. In sharp contrast, natural infection with equine influenza virus confers long-term protective immunity. In order to identify the protective immune responses to equine influenza virus, the influenza virus-specific IgA, IgGa, IgGb, IgGc and IgG(T) antibody responses in nasal secretions and serum induced by natural infection and a commercial vaccine were studied by ELISA. Two groups of four influenza-naiveponies were established. In the natural infection group, ponies received 10(8.5) EID50 of A/equine/Ky/1/81 by intranasal instillation, wereallowed to recover and then were rechallenged 100 days later: All four ponies exhibited clinical signs of influenza virus infection and virnl shedding following primary infection, but were completely protected from challenge infection. Antibody responses to primary infection were characterized by nasal IgA and serum IgGa and IgGb responses. Ponies in the conventional vaccine group received a commercially available vaccine by intramuscular injection followed by a booster injection 3 weeks later: Challenge infection 100 days after vaccination resulted inclinical signs of infection and viral shedding. Antibody responses tovaccination were restricted to serum IgG(T) responses only. These results demonstrate that the protective immunity generated by natural equine influenza vines infection is associated with a mucosal IgA immune response and humoral IgGa and IgGb sub-isotype responses, and that this pattern of response is not generated by conventional vaccines. (C) 1998 Elsevier Science Ltd All rights reserved.

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Documento generato il 08/07/20 alle ore 07:21:28