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Titolo:
CLONIDINE DOES NOT ATTENUATE MEDIAN NERVE SOMATOSENSORY-EVOKED POTENTIALS DURING ISOFLURANE ANESTHESIA
Autore:
PORKKALA T; JANTTI V; HAKKINEN V; KAUKINEN S;
Indirizzi:
TAMPERE UNIV HOSP,DEPT ANESTHESIA & INTENS CARE,POB 2000 FIN-33521 TAMPERE FINLAND OULU UNIV HOSP,DEPT CLIN NEUROPHYSIOL OULU FINLAND TAMPERE UNIV HOSP,DEPT CLIN NEUROPHYSIOL TAMPERE FINLAND TAMPERE UNIV HOSP,DEPT ANESTHESIA & INTENS CARE TAMPERE FINLAND
Titolo Testata:
JOURNAL OF CLINICAL MONITORING AND COMPUTING
fascicolo: 3, volume: 14, anno: 1998,
pagine: 165 - 170
SICI:
1387-1307(1998)14:3<165:CDNAMN>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDURAL CLONIDINE; ENDOTRACHEAL INTUBATION; HEMODYNAMIC-RESPONSE; NITROUS-OXIDE; REQUIREMENTS; ANALGESIA; SURGERY;
Keywords:
ANESTHETICS, ISOFLURANE; SYMPATHETIC NERVOUS SYSTEM, PHARMACOLOGY, CLONIDINE; BRAIN, EVOKED POTENTIALS, SOMATOSENSORY, EEG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T. Porkkala et al., "CLONIDINE DOES NOT ATTENUATE MEDIAN NERVE SOMATOSENSORY-EVOKED POTENTIALS DURING ISOFLURANE ANESTHESIA", JOURNAL OF CLINICAL MONITORING AND COMPUTING, 14(3), 1998, pp. 165-170

Abstract

Background. Clonidine, an alpha(2) agonist, reduces the requirements of several anesthetics. However, the effects of clonidine on somatosensory evoked potentials (SEPs) are unclear. These effects on cortical SEPs during isoflurane anesthesia were studied in 20 ASA I-II patients scheduled for elective surgery Furthermore, the isoflurane concentration required to induce electroencephalogram (EEG) burst-suppression with and without clonidine was studied. Methods. Anesthesia was maintained with isoflurane at a FIO2 of 0.4. At 1 MAC isoflurane the patients were randomly given either intravenous clonidine 2 IJ-g kg-l (ten patients) or saline (ten patients). Finally, the isoflurane concentration was increased to a point at which a burst-suppression pattern appeared in the EEG. SEPs upon median nerve stimulation were recorded (1) before induction of anesthesia, (2) at 1 MAC before clonidine/saline, (3) at 1 MAC after clonidine/saline, (I) at EEG burst-suppression. Results. The cortical SEP amplitude was attenuated from 3.7 (2.0) mu V to 2.1 (1.3) mu V (p < 0.001) and the peak latency increased from 19.3 (1.1) ms to 22.0 (1.3) ms (p < 0.0001) during 1 MAC isoflurane anesthesia, but the addition of clonidine did not further increase these changes. The isoflurane end-tidal concentration needed to induce burst-suppression EEG was not significantly different in the clonidine group comparedwith the placebo group (2.0% vs. 2.1%, P = 0.07). Conclusions. The effect of clonidine in reducing the requirements of anesthetics during general anesthesia is not seen in the cortical SEPs. The isoflurane-induced burst-suppression in the EEG was not affected by clonidine, suggesting that the EEG effects of clonidine and isoflurane were not additive. If SEPs are monitored intraoperatively, clonidine can be used as an adjuvant during isoflurane anesthesia without harmful effects on SEPmonitoring.

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Documento generato il 05/07/20 alle ore 01:05:21