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Titolo:
POLYMORPHISMS IN THE DOPAMINE, SEROTONIN, AND NOREPINEPHRINE TRANSPORTER GENES AND THEIR RELATIONSHIPS TO MONOAMINE METABOLITE CONCENTRATIONS IN CSF OF HEALTHY-VOLUNTEERS
Autore:
JONSSON EG; NOTHEN MM; GUSTAVSSON JP; NEIDT H; BUNZEL R; PROPPING P; SEDVALL GC;
Indirizzi:
KAROLINSKA INST,DEPT CLIN NEUROSCI,PSYCHIAT SECT SE-17176 STOCKHOLM SWEDEN UNIV BONN,INST HUMAN GENET D-53111 BONN GERMANY
Titolo Testata:
Psychiatry research
fascicolo: 1, volume: 79, anno: 1998,
pagine: 1 - 9
SICI:
0165-1781(1998)79:1<1:PITDSA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS LOCUS COERULEUS; CEREBROSPINAL-FLUID; LOCALIZATION; INDIVIDUALS; ASSOCIATION; INNERVATION; EXPRESSION; DEPRESSION;
Keywords:
DOPAMINE TRANSPORTER GENE; SEROTONIN TRANSPORTER GENE; NOREPINEPHRINE TRANSPORTER GENE; MONOAMINE METABOLITES (HVA, 5-HIAA, MHPG); CEREBROSPINAL FLUID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
E.G. Jonsson et al., "POLYMORPHISMS IN THE DOPAMINE, SEROTONIN, AND NOREPINEPHRINE TRANSPORTER GENES AND THEIR RELATIONSHIPS TO MONOAMINE METABOLITE CONCENTRATIONS IN CSF OF HEALTHY-VOLUNTEERS", Psychiatry research, 79(1), 1998, pp. 1-9

Abstract

Concentrations of monoamine metabolites (MM) in lumbar cerebrospinal fluid (CSF) have been used extensively as indirect estimates of monoamine turnover in the brain. We investigated the possible relationships between DNA polymorphisms in the dopamine transporter (DAT), serotonintransporter (SERT), and norepinephrine transporter (NET) genes and CSF concentrations of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n = 66). The DAT polymorphism was not significantly associatedwith any of the monoamine metabolites, but a tendency for relationship with 5-HIAA was found in women. For both of the two SERT polymorphisms investigated, a functional promoter polymorphism and an intronic polymorphism without known function, significant relationships were found with CSF MHPG levels. No relationship was found between the SERT polymorphisms and CSF HVA and 5-HIAA. The NET polymorphism was associatedwith CSF MHPG levels but not HVA and 5-HIAA concentrations. The results suggest that SERT and NET genotypes may participate differentially in the regulation of the norepinephrine turnover rate under presumed steady-state conditions in the central nervous system. As only limited data so far indicate interactions between the serotonin and norepinephrine systems in the brain, and the NET polymorphism investigated is not known to be of functional significance, the results should be interpreted with caution until replicated. (C) 1998 Elsevier Science IrelandLtd. All rights reserved.

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Documento generato il 21/01/20 alle ore 01:52:45