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Titolo:
CLOZAPINE METABOLISM RATE AS A POSSIBLE INDEX OF DRUG-INDUCED GRANULOCYTOPENIA
Autore:
MAURI MC; RUDELLI R; BRAVIN S; GIANETTI S; GIULIANI E; GUERRINI A; ORLANDI R; INVERNIZZI G;
Indirizzi:
UNIV MILAN,DEPT CLIN PSYCHIAT,CLIN NEUROPSYCHOPHARMACOL UNIT,IRCCS,OSPED MAGGIORE MILANO I-20122 MILAN ITALY GEN HOSP,DEPT PSYCHIAT MELEGNANO ITALY UNIV PAVIA,DEPT TOXICOL I-27100 PAVIA ITALY
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 137, anno: 1998,
pagine: 341 - 344
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED AGRANULOCYTOSIS; RISK-FACTORS; SERUM;
Keywords:
CLOZAPINE; METABOLISM; GRANULOCYTOPENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Mauri et al., "CLOZAPINE METABOLISM RATE AS A POSSIBLE INDEX OF DRUG-INDUCED GRANULOCYTOPENIA", Psychopharmacology, 137(4), 1998, pp. 341-344

Abstract

A possible relationship between haematological adverse reactions and clozapine (CLZ) metabolism rate was studied. Sixteen chronic schizophrenic outpatients (mean age 34.62 years +/- 7.56 SD) were treated with CLZ, 75-600 mg/daily for 9 weeks. CLZ and nor-clozapine (NCLZ) plasma levels were determined weekly, contemporarily with blood cell counts. CLZ plasma levels ranged from 25 to 1270 ng/ml (mean 266.27 ng/ml +/- 197.44 SD), while NCLZ plasma levels ranged from 25 to 1280 ng/ml (mean 169.0 ng/ml +/- 127.94 SD). NCLZ/CLZ ratio ranged from 0.13 to 1.72 (mean 0.72 +/- 0.28 SD). Leukocyte count ranged from 5.2 to 18.8 10(9)/1 (mean 9.37 10(9)/1 +/- 2.94 SD) and neutrophil count ranged from 1.8 to 13.4 10(9)/1 (mean 5.73 +/- 2.57 SD). No correlation was found between CLZ dosage and NCLZ plasma levels. Both CLZ and NCLZ plasma levels correlated positively with neutrophil count (CLZ: P = 0.001, r = 0.26; NCLZ: P = 0.01, r = 0.20). The correlation between NCLZ/CLZ plasmalevel ratio and neutrophil count was significantly negative (P = 0.002, r = 0.25). These preliminary data suggest that the NCLZ/CLZ ratio, as an index of CLZ metabolism, might be a possible risk factor associated with CLZ treatment.

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Documento generato il 18/01/20 alle ore 07:29:39