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Titolo:
DIFFERENTIAL-EFFECTS OF INTRATHECALLY ADMINISTERED N-TYPE AND P-TYPE VOLTAGE-SENSITIVE CALCIUM-CHANNEL BLOCKERS UPON 2 MODELS OF EXPERIMENTAL MONONEUROPATHY IN THE RAT
Autore:
YAMAMOTO T; SAKASHITA Y;
Indirizzi:
CHIBA UNIV,SCH MED,DEPT ANESTHESIOL,CHUO KU,1-8-1 INOHANA CHIBA 2600856 JAPAN
Titolo Testata:
Brain research
fascicolo: 2, volume: 794, anno: 1998,
pagine: 329 - 332
SICI:
0006-8993(1998)794:2<329:DOIANA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCIATIC-NERVE; NOCICEPTION; ANTAGONISTS; DISORDERS; FORMALIN; INJURY;
Keywords:
NEUROPATHIC PAIN; N-TYPE VOLTAGE-SENSITIVE CALCIUM CHANNEL; P-TYPE VOLTAGE-SENSITIVE CALCIUM CHANNEL; CHRONIC CONSTRICTION INJURY; PARTIAL SCIATIC NERVE INJURY; THERMAL HYPERALGESIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
T. Yamamoto e Y. Sakashita, "DIFFERENTIAL-EFFECTS OF INTRATHECALLY ADMINISTERED N-TYPE AND P-TYPE VOLTAGE-SENSITIVE CALCIUM-CHANNEL BLOCKERS UPON 2 MODELS OF EXPERIMENTAL MONONEUROPATHY IN THE RAT", Brain research, 794(2), 1998, pp. 329-332

Abstract

We investigated the effects of intrathecally administered N-type and P-type voltage-sensitive calcium channel (VSCC) blockers on the level of thermal hyperalgesia in two neuropathic pain models: the chronic constriction injury (CCI) model and the partial sciatic nerve injury (PSNI) model. N-type, but not P-type, VSCC blockers attenuated the level of thermal hyperalgesia induced by CCI in a dose-dependent manner. In the PSNI model, both N-type and P-type VSCC blockers had no effect on thermal hyperalgesia. This suggests that some types of neuropathic pain may be treatable with N-type VSCC blockers. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:14:26