Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
POSTHYPOXIC FREQUENCY DECLINE DOES NOT DEPEND ON ALPHA(2)-ADRENERGIC RECEPTORS IN THE ADULT-RAT
Autore:
COLES SK; ERNSBERGER P; DICK TE;
Indirizzi:
CASE WESTERN RESERVE UNIV,DEPT ANAT,DIV PULM & CRIT CARE MED,11100 EUCLID AVE CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT MED,DIV PULM & CRIT CARE MED CLEVELANDOH 44106
Titolo Testata:
Brain research
fascicolo: 2, volume: 794, anno: 1998,
pagine: 267 - 273
SICI:
0006-8993(1998)794:2<267:PFDDND>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY RHYTHM GENERATOR; SPRAGUE-DAWLEY RATS; NEWBORN RAT; LOCUS-CERULEUS; SPINAL-CORD; NEURONS; MODULATION; INVITRO; INNERVATION; CLONIDINE;
Keywords:
HYPOXIA; NORADRENALINE; RESPIRATION; RAT; PONS; GUANABENZ; POSTHYPOXIC FREQUENCY DECLINE; SK-AND-F-86466;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S.K. Coles et al., "POSTHYPOXIC FREQUENCY DECLINE DOES NOT DEPEND ON ALPHA(2)-ADRENERGIC RECEPTORS IN THE ADULT-RAT", Brain research, 794(2), 1998, pp. 267-273

Abstract

The aim of this study was to determine whether post-hypoxic frequencydecline (PHFD) requires central activation of alpha(2)-adrenergic receptors. PHFD is defined as the undershoot in respiratory frequency that occurs immediately following brief hypoxic periods. Adult anesthetized, vagotomized rats were exposed to hypoxia (8% O-2, mean = 45 s) before and after intracerebroventricular (i,c.v.) infusion of vehicle or alpha(2)-antagonist. The efficacy of the i.c.v. antagonist was assessed by recording the response to intravenous injection of alpha(2)-agonist before and after the infusion. We compared breathing frequencies before, during, and after hypoxia, both before and after treatments. Thedecline in breathing frequency after hypoxia was not prevented by thealpha(2)-antagonists, RX 821002 or SK&F-86466. Guanabenz, an alpha(2)-agonist, prolonged baseline expiration and potentiated PHFD. Prior treatment with SK&F-86466 blocked the agonist-evoked response which was also reversed by subsequent administration of SK&F-86466. We conclude that PHFD does not require the activation of alpha(2)-adrenergic receptors, but that alpha(2)-adrenergic receptors can modulate resting and post-hypoxic respiratory frequency. (C) 1998 Elsevier Science B.V. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:39:14