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Titolo:
PPAR-GAMMA ACTIVATORS IMPROVE GLUCOSE-HOMEOSTASIS BY STIMULATING FATTY-ACID UPTAKE IN THE ADIPOCYTES
Autore:
MARTIN G; SCHOONJANS K; STAELS B; AUWERX J;
Indirizzi:
INST PASTEUR,DEPT ATHEROSCLEROSE,INSERM,U325,1 RUE CALMETTE F-59019 LILLE FRANCE INST PASTEUR,DEPT ATHEROSCLEROSE,INSERM,U325 F-59019 LILLE FRANCE
Titolo Testata:
Atherosclerosis (Amsterdam)
, volume: 137, anno: 1998, supplemento:, S
pagine: 75 - 80
SICI:
0021-9150(1998)137:<75:PAIGBS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-C-III; FAMILIAL COMBINED HYPERLIPIDEMIA; INDUCED INSULIN-RESISTANCE; COA OXIDASE GENE; LIPOPROTEIN-LIPASE; RECEPTOR-GAMMA; TRANSCRIPTION FACTOR; DIABETES-MELLITUS; TRANSGENIC MICE; EXPRESSION;
Keywords:
FATTY ACIDS; GENE EXPRESSION; LIPID METABOLISM; NUCLEAR RECEPTORS; PEROXISOMES; TRANSCRIPTION FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
G. Martin et al., "PPAR-GAMMA ACTIVATORS IMPROVE GLUCOSE-HOMEOSTASIS BY STIMULATING FATTY-ACID UPTAKE IN THE ADIPOCYTES", Atherosclerosis (Amsterdam), 137, 1998, pp. 75-80

Abstract

It is currently thought that the effects of PPAR gamma activation on glucose homeostasis may be due to the effect of this nuclear receptor on the production of adipocyte-derived signalling molecules, which affect muscle glucose metabolism. Potential signalling molecules derived from adipocytes and modified by PPAR gamma activation include TNF alpha and leptin, which both interfere with glucose homeostasis. In addition to its effects on these proteins, PPAR gamma also profoundly affects fatty acid metabolism. Activation of PPAR gamma will selectively induce the expression of several genes involved in fatty acid uptake, such as lipoprotein lipase, fatty acid transport protein and acyl-CoA synthetase, in adipose tissue without changing their expression in muscletissue. This co-ordinate regulation of fatty acid partitioning by PPAR gamma results in an adipocyte 'FFA steal' causing a relative depletion of fatty acids in the muscle. Based on the well established interference of muscle fatty acid and glucose metabolism it is hypothesized that reversal of muscle fatty acid accumulation will contribute to the improvement in whole body glucose homeostasis. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:08:13