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Titolo:
CEREBRAL BLOOD-FLOW MEASUREMENT DURING EMBOLIZATION OF THE RAT-BRAIN USING THE XENON INJECTION METHOD
Autore:
OVERGAARD K; MEDEN P;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,KETTEGAARD ALLE 30 DK-2650 HVIDOVRE DENMARK UNIV HOSP COPENHAGEN,DEPT NEUROL,NEUROVASC RES LAB DK-2400 COPENHAGENDENMARK
Titolo Testata:
Neurological research
fascicolo: 5, volume: 20, anno: 1998,
pagine: 452 - 462
SICI:
0161-6412(1998)20:5<452:CBMDEO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBOLIC STROKE MODEL; ACID-BASE STATUS; INFARCT VOLUME; RT-PA; THROMBOLYTIC THERAPY; OXYGEN-CONSUMPTION; HYPERTENSIVE RATS; GAS TENSIONS; NEUROPROTECTION; AUTOREGULATION;
Keywords:
CEREBRAL BLOOD FLOW; (133)XENON INTRAARTERIAL INJECTION; STROKE; ACUTE ISCHEMIC STROKE; CEREBRAL INFARCTION AND EMBOLISM; EXPERIMENTAL THROMBOEMBOLISM; IN VITRO THROMBOTIC CLOTTING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
K. Overgaard e P. Meden, "CEREBRAL BLOOD-FLOW MEASUREMENT DURING EMBOLIZATION OF THE RAT-BRAIN USING THE XENON INJECTION METHOD", Neurological research, 20(5), 1998, pp. 452-462

Abstract

The purpose of this study was to investigate if cerebral blood flow (CBF) was influenced by the volume of the bolus using the intracarotid (133)Xenon method in anesthetized rats, and to evaluate the effect of intracarotid embolization on hemispheric CBF. In 18 male Sprague-Dawley rats hemispheric CBF was calculated from the recorded clearance of an intracarotid injected 50 mu l bolus of Xenon. A second clearance recording was done after the injection of a 200 mu l bolus of (133)Xenon. Then the 18 animals were divided in 3 subsets each of 6 animals. In the first subset of 6 animals a bolus of 200 mu l! (133)Xenon was given, clearance was recorded before and after the injection of a suspension of microemboli. In all the above experiments within 90sec after the initial bolus of (133)Xenon, 20 mu l (133)Xenon remaining in the carotid catheter was flushed into the brain by saline or the suspension of emboli. In the second subset of 6 rats the distribution of (133)Xenon in various parts: of the brain and head was examined after killing theanimals 35 sec after injection of a 200 mu l bolus of Xenon. The third subset of 6 rats was treated as the second subset, except for the size of the bolus which was 50 mu l of (133)Xenon. The calculated CBF values were independent of the volume of the bolus. At the post-mortem examination 76% of the radioactivity was located in the right hemisphere and the majority of the remainder in the head outside the brain. Theclearance curve was not monoexponential, but flattened out within theinitial 30 sec when clearance from areas with high CBF dominated the initial 15-second period, then clearance from areas with lower CBF values were more prominent in the following 15-second period. Embolization significantly reduced right hemispheric CBF to 0.26 (0.09-0.50) of the value immediately before embolization. The findings demonstrate applicability of CBF measurements using the intra-arterial (133)Xenon injection method during embolization of the rat brain, provided a second bolus of (133)Xenon is given before the embolization.

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Documento generato il 03/04/20 alle ore 03:23:58