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Titolo:
CONVENTIONAL ANTIHISTAMINES SLOW CARDIAC REPOLARIZATION IN ISOLATED-PERFUSED (LANGENDORFF) FELINE HEARTS
Autore:
WANG WX; EBERT SN; LIU XK; CHEN YW; DRICI MD; WOOSLEY RL;
Indirizzi:
GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL,3900 RESERVOIR RD NW WASHINGTON DC 20007 GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL WASHINGTON DC 20007
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 1, volume: 32, anno: 1998,
pagine: 123 - 128
SICI:
0160-2446(1998)32:1<123:CASCRI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADE-DE-POINTES; VENTRICULAR MYOCYTES; ASTEMIZOLE OVERDOSE; TERFENADINE; CHLORPHENIRAMINE; CARDIOTOXICITY; ANTAGONISTS; MECHANISM;
Keywords:
ANTIHISTAMINES; ECG; QT; CLEMASTINE; LANGENDORFF; HYDROXYZINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
W.X. Wang et al., "CONVENTIONAL ANTIHISTAMINES SLOW CARDIAC REPOLARIZATION IN ISOLATED-PERFUSED (LANGENDORFF) FELINE HEARTS", Journal of cardiovascular pharmacology, 32(1), 1998, pp. 123-128

Abstract

We examined the effects of ''conventional'' antihistamines on cardiacrepolarization by using the isolated perfused feline heart model. Representative drugs from the major classes of antihistamines were tested. Each of the antihistamines evaluated in this study elicited a dose-dependent slowing of cardiac repolarization, as indicated by the QT prolongations observed from electrocardiogram (ECG) tracings recorded during these experiments. The concentrations of drugs tested ranged from 1 to 30 mu M. Of the drugs analyzed, clemastine and hydroxyzine appeared to be the most potent (relative EC50 values, 5.2 and 6.6 mu M, respectively), causing the QT to lengthen by as much as 40-50% at a concentration of 10 mu M. Brompheniramine, chlorpheniramine, and diphenhydramine displayed intermediate potencies with respect to QT prolongation (relative EC50 Values, 11-13 mu M), whereas cyproheptadine, chlorcyclizine, and promethazine were the least potent of the antihistamines tested (relative EC50 values, 16-20 mu M). It is concluded that the antihistamines evaluated in this study act directly on the heart to slow cardiac repolarization. These findings could have important clinical relevance for patients taking excessive dosages of conventional antihistamines and those at risk of developing cardiac arrhythmias.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:05:07