Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
C-FOS GENE-EXPRESSION IS INDUCED IN A SUBPOPULATION OF STRIATAL NEURONS FOLLOWING A SINGLE ADMINISTRATION OF A DOPAMINE D1-RECEPTOR AGONISTIN ADULT RATS LESIONED WITH 6-OHDA AS NEONATES
Autore:
SOGHOMONIAN JJ; LAPRADE N; SANDSTROM M; BRUNO JP;
Indirizzi:
CHU LAVAL,CTR RECH,RC-9800,2705 BLVD LAURIER ST FOY PQ G1V 4G2 CANADA UNIV LAVAL,DEPT ANAT & PHYSIOL QUEBEC CITY PQ CANADA OHIO STATE UNIV,NEUROSCI PROGRAM COLUMBUS OH 43210
Titolo Testata:
Molecular brain research
fascicolo: 1, volume: 57, anno: 1998,
pagine: 155 - 160
SICI:
0169-328X(1998)57:1<155:CGIIIA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN DOPAMINE; SPINY NEURONS; RECEPTOR; 6-HYDROXYDOPAMINE; SUPERSENSITIVITY; RESPONSES; BEHAVIOR; D-1;
Keywords:
STRIATUM; 6-OHDA; DOPAMINE; PROTOONCOGENE; NEONATE; D1-RECEPTOR; MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Soghomonian et al., "C-FOS GENE-EXPRESSION IS INDUCED IN A SUBPOPULATION OF STRIATAL NEURONS FOLLOWING A SINGLE ADMINISTRATION OF A DOPAMINE D1-RECEPTOR AGONISTIN ADULT RATS LESIONED WITH 6-OHDA AS NEONATES", Molecular brain research, 57(1), 1998, pp. 155-160

Abstract

The effects of the dopamine D1 receptor agonist, SKF-38393, on the levels of mRNAs encoding for the proto-oncogene c-fos and the GABA-synthesizing enzyme glutamate decarboxylase (GAD65) were measured by in situ hybridization histochemistry in the striatum of adult rats depleted of dopamine as neonates, c-fos mRNA levels exhibited a prominent increase following the acute systemic administration of SKF-38393 in dopamine-depleted but not in normal rats. Double-labeling in situ hybridization histochemistry using a radioactive c-Sos probe and a digoxigenin-labeled preproenkephalin (PPE) cRNA probe indicated that c-fos mRNA levels were increased by SKF-38393 exclusively in a subpopulation of PPE-unlabeled neurons. Dopamine-depleted rats exhibited an increase in GAD65 mRNA levels relative to control rats. Acute administration of SKF-38393 did not alter GAD65 mRNA levels in control or in dopamine-depleted rats. Our results demonstrate that an acute administration of a D1-receptor agonist induces c-fos but not GAD65 gene expression in a subpopulation of presumed striato-nigral/entopeduncular neurons. They also suggest that the D1-dependent behavioral plasticity exhibited by adultrats depleted of dopamine as neonates is not the result of an alteredactivation of the two subpopulations of striatal efferent neurons. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:54:00